Aloe-emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride

B. Arosio, N. Gagliano, L. M P Fusaro, L. Parmeggiani, J. Tagliabue, P. Galetti, D. De Castri, C. Moscheni, G. Annoni

Research output: Contribution to journalArticle

Abstract

Aloe contains several active compounds including aloin, a C-glycoside that can be hydrolyzed in the gut to form aloe-emodin anthrone which, in turn, is auto-oxidized to the quinone aloe-emodin. On the basis of the claimed hepatoprotective activity of some antraquinones, we studied aloe-emodin in a rat model of carbon tetrachloride (CCl4) intoxication, since this xenobiotic induces acute liver damage by lipid peroxidation subsequent to free radical production. Twelve rats were treated with CCl4 (3 mg/kg) intraperitoneally and six were protected with two intraperitoneally injections of aloe-emodin (50 mg/kg; CCl4+aloe-emodin); six other rats were only aloe-emodin injected (aloe-emodin) and six were untreated (control). Histological examination of the livers showed less marked lesions in the CCl4+aloe-emodin rats than in those treated with CCl4 alone, and this was confirmed by the serum levels of L-aspartate-2-oxoglutate-aminotransferase (394±38.6 UI/l in CCl4, 280±24.47 UI/l in CCl4+aloe-emodin rats; P4 rats (P4+aloe-emodin rats. In contrast tumour necrosis factor-α mRNA was significantly higher (P4 than the control rats and almost equal in the CCl4+aloe-emodin, aloe-emodin and control groups. In conclusion, aloe-emodin appears to have some protective effect not only against hepatocyte death but also on the inflammatory response subsequent to lipid peroxidation.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalPharmacology and Toxicology
Volume87
Issue number5
Publication statusPublished - Nov 2000

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Carbon Tetrachloride
Liver
Wounds and Injuries
Rats
Lipid Peroxidation
benzoquinone
aloe emodin
Rat control
Aloe
Lipids
Xenobiotics
Transaminases
Aspartic Acid
Free Radicals
Hepatocytes
Tumor Necrosis Factor-alpha

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Pharmacology
  • Toxicology

Cite this

Arosio, B., Gagliano, N., Fusaro, L. M. P., Parmeggiani, L., Tagliabue, J., Galetti, P., ... Annoni, G. (2000). Aloe-emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride. Pharmacology and Toxicology, 87(5), 229-233.

Aloe-emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride. / Arosio, B.; Gagliano, N.; Fusaro, L. M P; Parmeggiani, L.; Tagliabue, J.; Galetti, P.; De Castri, D.; Moscheni, C.; Annoni, G.

In: Pharmacology and Toxicology, Vol. 87, No. 5, 11.2000, p. 229-233.

Research output: Contribution to journalArticle

Arosio, B, Gagliano, N, Fusaro, LMP, Parmeggiani, L, Tagliabue, J, Galetti, P, De Castri, D, Moscheni, C & Annoni, G 2000, 'Aloe-emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride', Pharmacology and Toxicology, vol. 87, no. 5, pp. 229-233.
Arosio B, Gagliano N, Fusaro LMP, Parmeggiani L, Tagliabue J, Galetti P et al. Aloe-emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride. Pharmacology and Toxicology. 2000 Nov;87(5):229-233.
Arosio, B. ; Gagliano, N. ; Fusaro, L. M P ; Parmeggiani, L. ; Tagliabue, J. ; Galetti, P. ; De Castri, D. ; Moscheni, C. ; Annoni, G. / Aloe-emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride. In: Pharmacology and Toxicology. 2000 ; Vol. 87, No. 5. pp. 229-233.
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AU - Arosio, B.

AU - Gagliano, N.

AU - Fusaro, L. M P

AU - Parmeggiani, L.

AU - Tagliabue, J.

AU - Galetti, P.

AU - De Castri, D.

AU - Moscheni, C.

AU - Annoni, G.

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