Aloe-emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride

B. Arosio, N. Gagliano, L. M P Fusaro, L. Parmeggiani, J. Tagliabue, P. Galetti, D. De Castri, C. Moscheni, G. Annoni

Research output: Contribution to journalArticlepeer-review

Abstract

Aloe contains several active compounds including aloin, a C-glycoside that can be hydrolyzed in the gut to form aloe-emodin anthrone which, in turn, is auto-oxidized to the quinone aloe-emodin. On the basis of the claimed hepatoprotective activity of some antraquinones, we studied aloe-emodin in a rat model of carbon tetrachloride (CCl4) intoxication, since this xenobiotic induces acute liver damage by lipid peroxidation subsequent to free radical production. Twelve rats were treated with CCl4 (3 mg/kg) intraperitoneally and six were protected with two intraperitoneally injections of aloe-emodin (50 mg/kg; CCl4+aloe-emodin); six other rats were only aloe-emodin injected (aloe-emodin) and six were untreated (control). Histological examination of the livers showed less marked lesions in the CCl4+aloe-emodin rats than in those treated with CCl4 alone, and this was confirmed by the serum levels of L-aspartate-2-oxoglutate-aminotransferase (394±38.6 UI/l in CCl4, 280±24.47 UI/l in CCl4+aloe-emodin rats; P4 rats (P4+aloe-emodin rats. In contrast tumour necrosis factor-α mRNA was significantly higher (P4 than the control rats and almost equal in the CCl4+aloe-emodin, aloe-emodin and control groups. In conclusion, aloe-emodin appears to have some protective effect not only against hepatocyte death but also on the inflammatory response subsequent to lipid peroxidation.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalPharmacology and Toxicology
Volume87
Issue number5
Publication statusPublished - Nov 2000

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Pharmacology
  • Toxicology

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