Alopecia neoplastica as a sign of visceral malignancies

a systematic review

G. Paolino, R. Pampena, S. Grassi, S. R. Mercuri, M. Cardone, P. Corsetti, E. Moliterni, M. Muscianese, A. Rossi, P. Frascione, C. Longo

Research output: Contribution to journalReview article

Abstract

Alopecia neoplastica (AN) from visceral tumours is a rare form of cutaneous metastasis in which internal malignancies spread to the scalp. The diagnosis of AN may be very challenging, especially when its onset precedes the diagnosis of the primary tumour. We aimed to improve the knowledge on AN, highlighting that in case of scarring localized alopecia, a differential diagnosis with metastasis should always be considered. We performed a systematic review to describe the main demographic and clinical features associated with AN from visceral malignancies; a survival analysis was also performed. In 118 reports, accounting for 123 patients, we found that women were more affected by AN than men (53.7% vs. 46.3%). The most frequent site of the primary tumour was the gastrointestinal tract (24.4%), followed by breast (17.9%), kidney (8.1%), lung (7.3%), thyroid (7.3%), uterus (6.5%), central nervous system (6.5%), liver (3.3%) and other anatomic areas for 18.7% of cases. Furthermore, in more than half of the cases (66.1%), AN lesions were single and were mainly diagnosed after the primary visceral tumour (71.5%). Finally, survival analysis highlighted a lower progression-free survival in men; while, no significant differences in overall survival were reported among genders. In conclusion, metastatic skin disease should always be taken into consideration when dealing with patients with localized scarring alopecia.

Original languageEnglish
JournalJournal of the European Academy of Dermatology and Venereology
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Alopecia
Neoplasms
Survival Analysis
Cicatrix
Neoplasm Metastasis
Scalp
Skin Diseases
Disease-Free Survival
Uterus
Gastrointestinal Tract
Thyroid Gland
Breast
Differential Diagnosis
Central Nervous System
Demography
Kidney
Lung
Skin
Survival
Liver

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

Alopecia neoplastica as a sign of visceral malignancies : a systematic review. / Paolino, G.; Pampena, R.; Grassi, S.; Mercuri, S. R.; Cardone, M.; Corsetti, P.; Moliterni, E.; Muscianese, M.; Rossi, A.; Frascione, P.; Longo, C.

In: Journal of the European Academy of Dermatology and Venereology, 01.01.2019.

Research output: Contribution to journalReview article

Paolino, G. ; Pampena, R. ; Grassi, S. ; Mercuri, S. R. ; Cardone, M. ; Corsetti, P. ; Moliterni, E. ; Muscianese, M. ; Rossi, A. ; Frascione, P. ; Longo, C. / Alopecia neoplastica as a sign of visceral malignancies : a systematic review. In: Journal of the European Academy of Dermatology and Venereology. 2019.
@article{325bbaab00b94f59af7252f34df5adfd,
title = "Alopecia neoplastica as a sign of visceral malignancies: a systematic review",
abstract = "Alopecia neoplastica (AN) from visceral tumours is a rare form of cutaneous metastasis in which internal malignancies spread to the scalp. The diagnosis of AN may be very challenging, especially when its onset precedes the diagnosis of the primary tumour. We aimed to improve the knowledge on AN, highlighting that in case of scarring localized alopecia, a differential diagnosis with metastasis should always be considered. We performed a systematic review to describe the main demographic and clinical features associated with AN from visceral malignancies; a survival analysis was also performed. In 118 reports, accounting for 123 patients, we found that women were more affected by AN than men (53.7{\%} vs. 46.3{\%}). The most frequent site of the primary tumour was the gastrointestinal tract (24.4{\%}), followed by breast (17.9{\%}), kidney (8.1{\%}), lung (7.3{\%}), thyroid (7.3{\%}), uterus (6.5{\%}), central nervous system (6.5{\%}), liver (3.3{\%}) and other anatomic areas for 18.7{\%} of cases. Furthermore, in more than half of the cases (66.1{\%}), AN lesions were single and were mainly diagnosed after the primary visceral tumour (71.5{\%}). Finally, survival analysis highlighted a lower progression-free survival in men; while, no significant differences in overall survival were reported among genders. In conclusion, metastatic skin disease should always be taken into consideration when dealing with patients with localized scarring alopecia.",
author = "G. Paolino and R. Pampena and S. Grassi and Mercuri, {S. R.} and M. Cardone and P. Corsetti and E. Moliterni and M. Muscianese and A. Rossi and P. Frascione and C. Longo",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/jdv.15498",
language = "English",
journal = "Journal of the European Academy of Dermatology and Venereology",
issn = "0926-9959",
publisher = "wiley",

}

TY - JOUR

T1 - Alopecia neoplastica as a sign of visceral malignancies

T2 - a systematic review

AU - Paolino, G.

AU - Pampena, R.

AU - Grassi, S.

AU - Mercuri, S. R.

AU - Cardone, M.

AU - Corsetti, P.

AU - Moliterni, E.

AU - Muscianese, M.

AU - Rossi, A.

AU - Frascione, P.

AU - Longo, C.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Alopecia neoplastica (AN) from visceral tumours is a rare form of cutaneous metastasis in which internal malignancies spread to the scalp. The diagnosis of AN may be very challenging, especially when its onset precedes the diagnosis of the primary tumour. We aimed to improve the knowledge on AN, highlighting that in case of scarring localized alopecia, a differential diagnosis with metastasis should always be considered. We performed a systematic review to describe the main demographic and clinical features associated with AN from visceral malignancies; a survival analysis was also performed. In 118 reports, accounting for 123 patients, we found that women were more affected by AN than men (53.7% vs. 46.3%). The most frequent site of the primary tumour was the gastrointestinal tract (24.4%), followed by breast (17.9%), kidney (8.1%), lung (7.3%), thyroid (7.3%), uterus (6.5%), central nervous system (6.5%), liver (3.3%) and other anatomic areas for 18.7% of cases. Furthermore, in more than half of the cases (66.1%), AN lesions were single and were mainly diagnosed after the primary visceral tumour (71.5%). Finally, survival analysis highlighted a lower progression-free survival in men; while, no significant differences in overall survival were reported among genders. In conclusion, metastatic skin disease should always be taken into consideration when dealing with patients with localized scarring alopecia.

AB - Alopecia neoplastica (AN) from visceral tumours is a rare form of cutaneous metastasis in which internal malignancies spread to the scalp. The diagnosis of AN may be very challenging, especially when its onset precedes the diagnosis of the primary tumour. We aimed to improve the knowledge on AN, highlighting that in case of scarring localized alopecia, a differential diagnosis with metastasis should always be considered. We performed a systematic review to describe the main demographic and clinical features associated with AN from visceral malignancies; a survival analysis was also performed. In 118 reports, accounting for 123 patients, we found that women were more affected by AN than men (53.7% vs. 46.3%). The most frequent site of the primary tumour was the gastrointestinal tract (24.4%), followed by breast (17.9%), kidney (8.1%), lung (7.3%), thyroid (7.3%), uterus (6.5%), central nervous system (6.5%), liver (3.3%) and other anatomic areas for 18.7% of cases. Furthermore, in more than half of the cases (66.1%), AN lesions were single and were mainly diagnosed after the primary visceral tumour (71.5%). Finally, survival analysis highlighted a lower progression-free survival in men; while, no significant differences in overall survival were reported among genders. In conclusion, metastatic skin disease should always be taken into consideration when dealing with patients with localized scarring alopecia.

UR - http://www.scopus.com/inward/record.url?scp=85062795588&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062795588&partnerID=8YFLogxK

U2 - 10.1111/jdv.15498

DO - 10.1111/jdv.15498

M3 - Review article

JO - Journal of the European Academy of Dermatology and Venereology

JF - Journal of the European Academy of Dermatology and Venereology

SN - 0926-9959

ER -