Alpha-1-antitrypsin (AAT) deposits in gall bladder adenocarcinoma and liver in partial AAT deficiency (Pi SZ phenotype)

F. Callea, J. M. Stuyck, G. Massi, J. D. Huyghe, D. F. Van Gijsegem, D. H. Jadoul, V. J. Desmet

Research output: Contribution to journalArticle

Abstract

Alpha-1-antitrypsin (AAT) immunoreactive inclusions were found in an adenocarcinoma of a gall bladder of a patient with Pi SZ phenotype who also had globular AAT accumulation in the liver. The inclusions did not react with antibodies against other plasma proteins, thus suggesting a primary synthesis of AAT in these cells. The presence of AAT in the tumor cells may represent resurgence of an oncofetal antigen, or, indirectly, may mean that AAT-containing cells normally exist in the human non-neoplastic gall bladder. The accumulation of AAT in tumor cells might be a basic process in malignant transformation.

Original languageEnglish
Pages (from-to)878-883
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume78
Issue number6
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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  • Cite this

    Callea, F., Stuyck, J. M., Massi, G., Huyghe, J. D., Van Gijsegem, D. F., Jadoul, D. H., & Desmet, V. J. (1982). Alpha-1-antitrypsin (AAT) deposits in gall bladder adenocarcinoma and liver in partial AAT deficiency (Pi SZ phenotype). American Journal of Clinical Pathology, 78(6), 878-883.