Alpha-1-antitrypsin in malakoplakia

Francesco Callea, Boudewijn Van Damme, Valeer J. Desmet

Research output: Contribution to journalArticlepeer-review


Macrophages in malakoplakia contain large amounts of immuno-reactive alpha-1-antitrypsin (AAT). The amount of AAT remains unchanged during the morphogenetic stages of the pathological process (early, granulomatous, fibrosing phases), and does not correlate with the number or the presence of Michaelis-Gutmann (M.G.) bodies. Macrophages from other pathological processes, closely resembling malakoplakia cells but without M.G. bodies, did not contain AAT, except for a few macrophages in tuberculosis and xanthogranulomatous pyelonephritis. Whatever the source and the pathogenic role of AAT in malakoplakia, its presence in all macrophages seems to be specific for this disease. Immuno-histochemical staining for AAT is therefore proposed as a useful test for an early and accurate differential diagnosis of malakoplakia.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalVirchows Archiv A Pathological Anatomy and Histology
Issue number1
Publication statusPublished - Mar 1982


  • Alpha-1-antitrypsin
  • Gutmann bodies
  • Immunohistochemistry
  • Macrophages
  • Malakoplakia
  • Michaelis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Anatomy


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