Alpha-1-antitrypsin phenotypes in malignant lymphoma

Francesco Callea, Guido Massi, Chris De Wolf-Peeters, Carl Lievens, Valeer J. Desmet

Research output: Contribution to journalArticle

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Abstract

The alpha-1-antitrypsin (α1, AT) Pi phenotypes have been determined by isoelectric focusing in a series of 228 patients having a histologically diagnosed malignant lymphoma and in 250 healthy controls. The Pi MZ phenotype occurred in 13 patients with lymphoma (5.8%) and in five of 250 healthy individuals (2%). Furthermore, one patient with a Pi SS and three patients with an abnormal unknown phenotype, migrating slower than Z, were found in the lymphoma group. No prevalence for a special lymphoma type was observed among the abnormal Pi phenotype patients. The increased incidence of abnormal Pi phenotypes in malignant lymphoma's support the hypothesis of the possible role of α1, AT in development of immunopathological disorders.

Original languageEnglish
Pages (from-to)1213-1215
Number of pages3
JournalJournal of Clinical Pathology
Volume35
Issue number11
DOIs
Publication statusPublished - 1982

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alpha 1-Antitrypsin
Lymphoma
Phenotype
Isoelectric Focusing
Incidence

ASJC Scopus subject areas

  • Health Policy
  • Pathology and Forensic Medicine

Cite this

Callea, F., Massi, G., De Wolf-Peeters, C., Lievens, C., & Desmet, V. J. (1982). Alpha-1-antitrypsin phenotypes in malignant lymphoma. Journal of Clinical Pathology, 35(11), 1213-1215. https://doi.org/10.1136/jcp.35.11.1213

Alpha-1-antitrypsin phenotypes in malignant lymphoma. / Callea, Francesco; Massi, Guido; De Wolf-Peeters, Chris; Lievens, Carl; Desmet, Valeer J.

In: Journal of Clinical Pathology, Vol. 35, No. 11, 1982, p. 1213-1215.

Research output: Contribution to journalArticle

Callea, F, Massi, G, De Wolf-Peeters, C, Lievens, C & Desmet, VJ 1982, 'Alpha-1-antitrypsin phenotypes in malignant lymphoma', Journal of Clinical Pathology, vol. 35, no. 11, pp. 1213-1215. https://doi.org/10.1136/jcp.35.11.1213
Callea, Francesco ; Massi, Guido ; De Wolf-Peeters, Chris ; Lievens, Carl ; Desmet, Valeer J. / Alpha-1-antitrypsin phenotypes in malignant lymphoma. In: Journal of Clinical Pathology. 1982 ; Vol. 35, No. 11. pp. 1213-1215.
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