Alpha-2-macroglobulin gene, oxidized low-density lipoprotein receptor-1 locus, and sporadic Alzheimer's disease

Anna Maria Colacicco, Vincenzo Solfrizzi, Alessia D'Introno, Cristiano Capurso, Patrick G. Kehoe, Davide Seripa, Alberto Pilotto, Andrea Santamato, Antonio Capurso, Francesco Panza

Research output: Contribution to journalArticlepeer-review

Abstract

A total sample of 169 AD patients, and 264 age- and sex-matched unrelated caregivers from Apulia, southern Italy, were genotypized for alpha-2-macroglobulin (A2M) Val1000/Ile single-nucleotide polymorphism (SNP) (rs669), apolipoprotein E (APOE), and SNPs (+1073 and +1071) in the oxidized low-density lipoprotein receptor-1 (OLR1) gene on chromosome 12. A2M allele and genotype frequencies were similar between AD patients and controls, also after stratification for late onset (≥70 years) and early onset (

Original languageEnglish
Pages (from-to)1518-1520
Number of pages3
JournalNeurobiology of Aging
Volume30
Issue number9
DOIs
Publication statusPublished - Sep 2009

Keywords

  • Alpha-2-macroglobulin (A2M)
  • Alzheimer's disease
  • Apolipoprotein E
  • Chromosome 12
  • Dementia
  • Oxidized low-density lipoprotein receptor-1 (OLR1)

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

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