Alpha and beta EEG power reflects L-dopa acute administration in parkinsonian patients

Jean Marc Melgari, Giuseppe Curcio, Francesca Mastrolilli, Gaetano Salomone, Laura Trotta, Mario Tombini, Lazzaro Di Biase, Federica Scrascia, Rita Fini, Emma Fabrizio, Paolo Maria Rossini, Fabrizio Vernieri

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Abstract

Aim. To evaluate the effect of an acute L-dopa administration on eye-closed resting state electroencephalographic (EEG) activity of cognitively preserved Parkinsonian patients. Methods. We examined 24 right-handed patients diagnosed as uncomplicated probable Parkinson's disease (PD). Each patient underwent UPDRS-part-III evaluation before and 60 minutes after an oral load of L dopa-methyl-ester/carbidopa 250/25 mg. Resting condition eyes-closed EEG data were recorded both pre- and post L-dopa load. Absolute EEG power values were calculated at each scalp derivation for Delta, Theta, Alpha and Beta frequency bands. UPDRS scores (both global and subscale scores) and EEG data (power values of different frequency bands for each scalp derivation) were submitted to a statistical analysis to compare Pre e Post L-Dopa conditions. Finally, a correlation analysis was carried out between EEG spectral content and UPDRS scores. Results. Considering EEG power spectral analysis, no statistically significant differences arose on Delta and Theta bands after L-dopa intake. Conversely, Alpha and Beta rhythms significantly increased on centro-parietal scalp derivations, as a function of L-dopa administration. Correlation analysis indicated a significant negative correlation between Beta power increase on centro-parietal areas and UPDRS subscores (Rigidity of arms and Bradykinesia). A minor significant negative correlation was also found between Alpha band increase and resting tremor. Conclusions. Assuming that a significant change in EEG power spectrum after L-dopa intake may be related to dopaminergic mechanisms, our findings are consistent with the hypothesis that dopaminergic defective networks are implicated in cortical oscillatory abnormalities at rest in non-demented PD patients.

Original languageEnglish
Article number302
JournalFrontiers in Aging Neuroscience
Volume6
Issue numberOCT
DOIs
Publication statusPublished - 2014

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Keywords

  • Alpha rhythm
  • Beta rhythm
  • Levodopa
  • Parkinson's disease
  • Power spectrum analysis
  • Quantitative EEG

ASJC Scopus subject areas

  • Ageing
  • Cognitive Neuroscience

Cite this

Melgari, J. M., Curcio, G., Mastrolilli, F., Salomone, G., Trotta, L., Tombini, M., Biase, L. D., Scrascia, F., Fini, R., Fabrizio, E., Rossini, P. M., & Vernieri, F. (2014). Alpha and beta EEG power reflects L-dopa acute administration in parkinsonian patients. Frontiers in Aging Neuroscience, 6(OCT), [302]. https://doi.org/10.3389/fnagi.2014.00302