Alpha, beta and gamma Human Papillomaviruses in the anal canal of HIV-infected and uninfected men who have sex with men

Maria Gabriella Donà, Tarik Gheit, Alessandra Latini, Maria Benevolo, Montserrat Torres, Vitaly Smelov, Sandrine McKay-Chopin, Amalia Giglio, Antonio Cristaudo, Mauro Zaccarelli, Massimo Tommasino, Massimo Giuliani

Research output: Contribution to journalArticle

Abstract

Objectives: Anal infection by cutaneous Human Papillomaviruses (HPV) has been rarely investigated. We aimed to assess the prevalence, genotype diversity, and determinants of mucosal (alpha) and cutaneous (beta and gamma) anal HPV infection in men who have sex with men (MSM). Methods: Anal samples were collected with a Dacron swab. Alpha HPVs were detected using the Linear Array HPV genotyping test, while beta and gamma HPVs using a PCR combined with Luminex technology. Results: A total of 609 MSM (437 HIV-uninfected and 172 HIV-infected, most of which were undergoing cART) were enrolled. Alpha, beta, and gamma HPVs were detected in 78.0%, 27.6% and 29.3% of the participants. Only alpha HPV prevalence was significantly higher among HIV-infected compared to uninfected MSM (93.0% vs. 72.1%, p

Original languageEnglish
Pages (from-to)74-84
Number of pages11
JournalJournal of Infection
Volume71
Issue number1
DOIs
Publication statusPublished - Jul 1 2015

Keywords

  • Anal canal
  • Cutaneous
  • HIV
  • Human Papillomavirus
  • Infection
  • Men who have sex with men
  • Mucosal

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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