TY - JOUR
T1 - Alpha, beta and gamma Human Papillomaviruses in the anal canal of HIV-infected and uninfected men who have sex with men
AU - Donà, Maria Gabriella
AU - Gheit, Tarik
AU - Latini, Alessandra
AU - Benevolo, Maria
AU - Torres, Montserrat
AU - Smelov, Vitaly
AU - McKay-Chopin, Sandrine
AU - Giglio, Amalia
AU - Cristaudo, Antonio
AU - Zaccarelli, Mauro
AU - Tommasino, Massimo
AU - Giuliani, Massimo
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Objectives: Anal infection by cutaneous Human Papillomaviruses (HPV) has been rarely investigated. We aimed to assess the prevalence, genotype diversity, and determinants of mucosal (alpha) and cutaneous (beta and gamma) anal HPV infection in men who have sex with men (MSM). Methods: Anal samples were collected with a Dacron swab. Alpha HPVs were detected using the Linear Array HPV genotyping test, while beta and gamma HPVs using a PCR combined with Luminex technology. Results: A total of 609 MSM (437 HIV-uninfected and 172 HIV-infected, most of which were undergoing cART) were enrolled. Alpha, beta, and gamma HPVs were detected in 78.0%, 27.6% and 29.3% of the participants. Only alpha HPV prevalence was significantly higher among HIV-infected compared to uninfected MSM (93.0% vs. 72.1%, p
AB - Objectives: Anal infection by cutaneous Human Papillomaviruses (HPV) has been rarely investigated. We aimed to assess the prevalence, genotype diversity, and determinants of mucosal (alpha) and cutaneous (beta and gamma) anal HPV infection in men who have sex with men (MSM). Methods: Anal samples were collected with a Dacron swab. Alpha HPVs were detected using the Linear Array HPV genotyping test, while beta and gamma HPVs using a PCR combined with Luminex technology. Results: A total of 609 MSM (437 HIV-uninfected and 172 HIV-infected, most of which were undergoing cART) were enrolled. Alpha, beta, and gamma HPVs were detected in 78.0%, 27.6% and 29.3% of the participants. Only alpha HPV prevalence was significantly higher among HIV-infected compared to uninfected MSM (93.0% vs. 72.1%, p
KW - Anal canal
KW - Cutaneous
KW - HIV
KW - Human Papillomavirus
KW - Infection
KW - Men who have sex with men
KW - Mucosal
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U2 - 10.1016/j.jinf.2015.02.001
DO - 10.1016/j.jinf.2015.02.001
M3 - Article
C2 - 25698067
AN - SCOPUS:84930540507
VL - 71
SP - 74
EP - 84
JO - Journal of Infection
JF - Journal of Infection
SN - 0163-4453
IS - 1
ER -