Acido alfa-linolenico e malattie cardiovascolari. Gli omega-3 oltre l'acido eicosapentaenoico e l'acido docosaesanoico

Translated title of the contribution: Alpha-linolenic acid and cardiovascular diseases omega-3 fatty acids beyond eicosapentaenoic acid and docosahexaenoic acid

F. Nannicini, F. Sofi, G. Avanzi, R. Abbate, G. F. Gensini

Research output: Contribution to journalArticle

Abstract

Over the last decades, an increasing body of evidence has been accumulated on the beneficial effect of polyunsaturated fatty adds both in primary and secondary prevention of cardiovascular diseases. However, the vast majority of the studies has been performed on long-chain polyunsaturated fatty acids, such as docosahexaenoic acid (DHA) and eicosapentaenoic add (EPA) and not on their biochemical precursor, alpha-linoknic add (ALA). Actually, ALA has some other beneficial effects apart from the known antiarrhythmic effect. In fact, ALA has a strong inhibitory effect on omega-6 metabolic pathway. An adequate daily intake of ALA shifts metabolic pathway to EPA, so favoring the formation of products with a predominant antiaggregating and vasorelaxing action, with respect to eicosanoids with a predominant thrombotic effect. Some important evidences have been raised on the association between ALA and cardiovascular mortality. Indeed, dietary ALA has been associated with a lower rate of fatal and nonfatal coronary events. Hence, major scientific associations published nutritional guidelines including a specific recommendation for ALA.

Translated title of the contributionAlpha-linolenic acid and cardiovascular diseases omega-3 fatty acids beyond eicosapentaenoic acid and docosahexaenoic acid
Original languageItalian
Pages (from-to)431-442
Number of pages12
JournalMinerva Cardioangiologica
Volume54
Issue number4
Publication statusPublished - Aug 2006

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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