Alpha-melanocyte-stimulating hormone is present in the inferior petrosal sinuses in patients with cushing’s disease

Annamaria Colao, Bartolomeo Merola, Mauro Cataldi, Giuseppe La Tessa, Françoise Boudouresque, Charles Oliver, Gianfranco Di Renzo, Lucio Annunziat, Gaetano Lombards

Research output: Contribution to journalArticle

Abstract

Plasma ACTH, β-endorphin and α-melanocyte-stimulating hormone levels were evaluated in the inferior petrosal sinuses and in the periphery of 22 patients affected by Cushing’s disease, 11 patients with other pituitary diseases subjected to simultaneous and bilateral inferior petrosal sinus sampling and in the peripheral blood of 15 normal subjects. In patients with Cushing’s disease ACTH, β-endorphin and α-melanocyte-stimulating hormone levels in the inferior petrosal sinus ipsilateral to the adenoma were significantly higher than in the periphery and in the contralateral inferior petrosal sinus (p <0.01, p <0.01 and p <0.05, respectively). In patients with other pituitary diseases only ACTH and β-endorphin, but not α-melanocyte-stimulating hormone levels in both inferior petrosal sinuses were significantly higher than in the periphery (p <0.01). Furthermore, no difference was found in the peripheral blood among patients with Cushing’s disease, patients with other pituitary diseases and normal subjects for ACTH and β-endorphin level. By contrast, in patients with Cushing’s disease peripheral α-melanocyte-stimulating hormone levels were significantly higher than in patients with other pituitary diseases and in normal subjects (p <0.05). In conclusion, the results of the present study suggest that only in patients with Cushing’s disease, but not in patients with other pituitary diseases, α-melanocyte-stimulating hormone is released by adenomatous pituitary corticotrophs together with ACTH and β-endorphin.

Original languageEnglish
Pages (from-to)227-233
Number of pages7
JournalNeuroendocrinology
Volume58
Issue number2
DOIs
Publication statusPublished - 1993

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Keywords

  • ACTH
  • Cushing’s disease
  • Inferior petrosal sinus sampling
  • α-MSH
  • β-Endorphin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)

Cite this

Colao, A., Merola, B., Cataldi, M., Tessa, G. L., Boudouresque, F., Oliver, C., Renzo, G. D., Annunziat, L., & Lombards, G. (1993). Alpha-melanocyte-stimulating hormone is present in the inferior petrosal sinuses in patients with cushing’s disease. Neuroendocrinology, 58(2), 227-233. https://doi.org/10.1159/000126537