Alpha-synuclein: From early synaptic dysfunction to neurodegeneration

Veronica Ghiglieri, Valeria Calabrese, Paolo Calabresi

Research output: Contribution to journalReview articlepeer-review


Over the last two decades, many experimental and clinical studies have provided solid evidence that alpha-synuclein (α-syn), a small, natively unfolded protein, is closely related to Parkinson's disease (PD) pathology. To provide an overview on the different roles of this protein, here we propose a synopsis of seminal and recent studies that explored the many aspects of α-syn. Ranging from the physiological functions to its neurodegenerative potential, the relationship with the possible pathogenesis of PD will be discussed. Close attention will be paid on early cellular and molecular alterations associated with the presence of α-syn aggregates.

Original languageEnglish
Article number295
JournalFrontiers in Neurology
Issue numberMAY
Publication statusPublished - May 4 2018


  • Experimental parkinsonism
  • Neurodegeneration
  • Protein aggregation
  • Synaptic plasticity
  • Synucleinopathy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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