Abstract
We applied RT-QuIC assay to detect alpha-synuclein aggregates in cerebrospinal fluid (CSF) of patients with suspected Creutzfeldt-Jakob disease who had a neuropathological diagnosis of dementia with Lewy bodies (DLB) (n = 7), other neurodegenerative diseases with alpha-synuclein mixed pathology (n = 20), or without Lewy-related pathology (n = 49). The test had a sensitivity of 92.95.9synucleinopathies from non-alpha-synucleinopathies. When performed in the CSF of patients with DLB (n = 36), RT-QuIC was positive in 17/20 with probable DLB, 0/6 with possible DLB, and 0/10 with Alzheimer disease. These results indicate that RT-QuIC for alpha-synuclein is an accurate test for DLB diagnosis.
Original language | English |
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Pages (from-to) | 2120-2126 |
Number of pages | 7 |
Journal | Annals of Clinical and Translational Neurology |
Volume | 6 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 1 2019 |