Alpha1-antitrypsin deficiency and asthma

Asthma and Alpha1-Antitrypsin Research Group

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE OF REVIEW: The aim of the article is to highlight the association between α1-antitrypsin deficiency (AATD) and asthma. RECENT FINDINGS: AATD is one of the most common and underrecognized autosomal disorders associated with an increased risk of developing liver and lung diseases. An association between α1-antitrypsin and asthma has been suggested, especially with severe forms of this disease. Many studies have shown an increased prevalence of asthma in the α1-antitrypsin-deficient population overtime (4-38%). The biological mechanism underlying these two conditions and able to bind them has not yet been well investigated. As α1-antitrypsin is the main inhibitor of the serine proteinase and it is an important anti-inflammatory protein with pronounced immunomodulatory activities, it can be hypothesized that the link between AATD and asthma might be represented by the elastase/antielastase imbalance and the proinflammatory effect that occurs because of the reduction of this protein. SUMMARY: There is a strong need for further researches to better understand the molecular mechanisms binding AATD and asthma. It is also recommendable to screen for AATD, late-onset asthma patients, and/or those with not fully reversible airways obstruction.

Original languageEnglish
Pages (from-to)46-51
Number of pages6
JournalCurrent Opinion in Allergy and Clinical Immunology
Volume21
Issue number1
DOIs
Publication statusPublished - Feb 1 2021

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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