Alpha2-macroglobulin levels are high in adult patients with congenital antithrombin deficiency

Armando Tripodi, Veena Chantarangkul, Valerio De Stefano, Piermannuccio Mannucci

Research output: Contribution to journalArticlepeer-review


Antithrombin is responsible for about 80% of the progressive inhibitory activity of thrombin in human plasma. The role of other protease inhibitors known to inhibit thrombin is not completely clarified. However, their contribution may become relevant when antithrombin is low. We elected to investigate adult patients with congenital antithrombin deficiency to assess the concentration of other naturally occurring thrombin inhibitors such as alpha2-macroglobulin, alpha1-antitrypsin, heparin cofactor II, and C1-inhibitor. The study included 59 patients with congenital antithrombin deficiency with and without a previous history of thrombosis, together with an equal number of control subjects matched for age and sex. Statistically significant differences (patients vs. controls) were observed only for alpha2-macroglobulin (i.e., 120 vs. 102%, p2-macroglobulin levels were higher than the 90th percentile of control distribution more often in asymptomatic than symptomatic men (odds ratio=0.04; confidence interval=0.003-0.60), but not in women (odds ratio=2.14; confidence interval=0.35-13.1). In conclusion, results from this cross sectional study showed that alpha2-macroglobulin levels were high in patients with congenital antithrombin deficiency. Furthermore, the high levels were found more often in asymptomatic than symptomatic men. Whether this increase provides protection against thrombosis should be evaluated in a prospective study. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalThrombosis Research
Issue number2
Publication statusPublished - Apr 15 2000


  • Alpha-macroglobulin
  • Antithrombin deficiency
  • CI, confidence interval
  • Inherited thrombophilia
  • Natural anticoagulants
  • Serine protease inhibitors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology


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