Alrp, a survival factor that controls the apoptotic process of regenerating liver after partial hepatectomy in rats

Lorenzo Polimeno, Barbara Pesetti, Emanuele Annoscia, Floriana Giorgio, Ruggiero Francavilla, Thomas Lisowsky, Antonietta Gentile, Roberta Rossi, Antongiulio Bucci, Antonio Francavilla

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Augmenter of Liver Regeneration (Alrp) enhances, through unknown mechanism/s, hepatocyte proliferation only when administered to partially hepatectomized (PH) rats. Liver resection, besides stimulating hepatocyte proliferation, induces reactive oxygen species (ROS), triggering apoptosis. To clarify the role of Alrp in the process of liver regeneration, hepatocyte proliferation, apoptosis, ROS-induced parameters and morphological findings of regenerating liver were studied from PH rats Alrp-treated for 72 h after the surgery. The same parameters, evaluated on regenerating liver from albumin-treated PH rats, were used as control. The results demonstrated that Alrp administration induces the anti-apoptotic gene expression, inhibits hepatocyte apoptosis and reduces ROS-induced cell damage. These and similar data from in vitro studies and the presence of 'Alrp homologous proteins' in viruses as well as in mammals (i) allow to hypothesize that Alrp activity/ies may not be exclusive for regenerating liver and (ii) suggest the use of Alrp in the treatment of oxidative stress-related diseases.

Original languageEnglish
Pages (from-to)534-549
Number of pages16
JournalFree Radical Research
Volume45
Issue number5
DOIs
Publication statusPublished - May 2011

Fingerprint

Hepatectomy
Liver
Rats
Hepatocytes
Reactive Oxygen Species
Liver Regeneration
Apoptosis
Mammals
Albumins
Oxidative Stress
Oxidative stress
Viruses
Gene Expression
Gene expression
Surgery
Cells
Proteins

Keywords

  • hepatocyte survival
  • Liver regeneration
  • mitochondrial protection
  • oxidative stress

ASJC Scopus subject areas

  • Biochemistry

Cite this

Polimeno, L., Pesetti, B., Annoscia, E., Giorgio, F., Francavilla, R., Lisowsky, T., ... Francavilla, A. (2011). Alrp, a survival factor that controls the apoptotic process of regenerating liver after partial hepatectomy in rats. Free Radical Research, 45(5), 534-549. https://doi.org/10.3109/10715762.2011.555482

Alrp, a survival factor that controls the apoptotic process of regenerating liver after partial hepatectomy in rats. / Polimeno, Lorenzo; Pesetti, Barbara; Annoscia, Emanuele; Giorgio, Floriana; Francavilla, Ruggiero; Lisowsky, Thomas; Gentile, Antonietta; Rossi, Roberta; Bucci, Antongiulio; Francavilla, Antonio.

In: Free Radical Research, Vol. 45, No. 5, 05.2011, p. 534-549.

Research output: Contribution to journalArticle

Polimeno, L, Pesetti, B, Annoscia, E, Giorgio, F, Francavilla, R, Lisowsky, T, Gentile, A, Rossi, R, Bucci, A & Francavilla, A 2011, 'Alrp, a survival factor that controls the apoptotic process of regenerating liver after partial hepatectomy in rats', Free Radical Research, vol. 45, no. 5, pp. 534-549. https://doi.org/10.3109/10715762.2011.555482
Polimeno, Lorenzo ; Pesetti, Barbara ; Annoscia, Emanuele ; Giorgio, Floriana ; Francavilla, Ruggiero ; Lisowsky, Thomas ; Gentile, Antonietta ; Rossi, Roberta ; Bucci, Antongiulio ; Francavilla, Antonio. / Alrp, a survival factor that controls the apoptotic process of regenerating liver after partial hepatectomy in rats. In: Free Radical Research. 2011 ; Vol. 45, No. 5. pp. 534-549.
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