ALS clinical trials: Do enrolled patients accurately represent the ALS population?

A. Chiò, A. Canosa, S. Gallo, S. Cammarosano, C. Moglia, G. Fuda, A. Calvo, G. Mora

Research output: Contribution to journalArticle

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Abstract

Objective: To assess the effect of eligibility criteria in amyotrophic lateral sclerosis (ALS) clinical trials on the representativeness of the enrolled population. Methods: Patients enrolled in 8 placebo-controlled clinical trials in our ALS center from 2003 to 2008 were compared 1) to the patients included a prospective epidemiologic register (Piemonte and Valle d'Aosta register for ALS, PARALS) in the same period and 2) the subset of PARALS patients who met the usual criteria for inclusion in clinical trials (PARALS-ct) (definite, probable, probable laboratory-supported ALS; age between 18 and 75 years; disease duration

Original languageEnglish
Pages (from-to)1432-1437
Number of pages6
JournalNeurology
Volume77
Issue number15
DOIs
Publication statusPublished - Oct 11 2011

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Amyotrophic Lateral Sclerosis
Clinical Trials
Population
Controlled Clinical Trials
Placebos

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Chiò, A., Canosa, A., Gallo, S., Cammarosano, S., Moglia, C., Fuda, G., ... Mora, G. (2011). ALS clinical trials: Do enrolled patients accurately represent the ALS population? Neurology, 77(15), 1432-1437. https://doi.org/10.1212/WNL.0b013e318232ab9b

ALS clinical trials : Do enrolled patients accurately represent the ALS population? / Chiò, A.; Canosa, A.; Gallo, S.; Cammarosano, S.; Moglia, C.; Fuda, G.; Calvo, A.; Mora, G.

In: Neurology, Vol. 77, No. 15, 11.10.2011, p. 1432-1437.

Research output: Contribution to journalArticle

Chiò, A, Canosa, A, Gallo, S, Cammarosano, S, Moglia, C, Fuda, G, Calvo, A & Mora, G 2011, 'ALS clinical trials: Do enrolled patients accurately represent the ALS population?', Neurology, vol. 77, no. 15, pp. 1432-1437. https://doi.org/10.1212/WNL.0b013e318232ab9b
Chiò A, Canosa A, Gallo S, Cammarosano S, Moglia C, Fuda G et al. ALS clinical trials: Do enrolled patients accurately represent the ALS population? Neurology. 2011 Oct 11;77(15):1432-1437. https://doi.org/10.1212/WNL.0b013e318232ab9b
Chiò, A. ; Canosa, A. ; Gallo, S. ; Cammarosano, S. ; Moglia, C. ; Fuda, G. ; Calvo, A. ; Mora, G. / ALS clinical trials : Do enrolled patients accurately represent the ALS population?. In: Neurology. 2011 ; Vol. 77, No. 15. pp. 1432-1437.
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