ALS multidisciplinary clinic and survival: Results from a population-based study in Southern Italy

Stefano Zoccolella, Ettore Beghi, Guerrino Palagano, Angela Fraddosio, Vito Guerra, Vito Lepore, Isabella Laura Simone, Paolo Lamberti, Luigi Serlenga, Giancarlo Logroscino

Research output: Contribution to journalArticlepeer-review


Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting motorneurons, for which there is no effective cure. Because of the multifactorial nature of impairment and disablity in ALS, multidisciplinary clinics (MDC) have been recently introduced in the management of ALS patients; their effects on survival remain, however, largely debated. Objective: To compare survival of ALS patients who received their care at MDC with that of patients followed by general neurology clinics. Methods: Source of the study was a prospective population-based registry of ALS established in Puglia, Southern Italy, in 1997. We examined survival of 126 out of 130 incident ALS cases that were diagnosed during the period 1998-99. 84 patients (67%) were enrolled and followed by MDC and the remaining 42 (33%) by general neurological clinics. No difference in median survival time from the diagnosis was observed between patients followed by ALS multidisciplinary (17.6 months) and general clinics (18 months). No beneficial effect was present among bulbar onset ALS (11.7 versus 23 months). In multivariate analysis management by ALS MDC was associated with only a 10% increase in survival probability at 12 months (HR: 0.91; 95%CI: 0.44-1.89; p = 0.9). Conclusions: In this population-based series, we found that in Southern Italy management of ALS by multidisciplinary clinics does not improve survival, regardless of site of symptoms onset.

Original languageEnglish
Pages (from-to)1107-1112
Number of pages6
JournalJournal of Neurology
Issue number8
Publication statusPublished - Aug 2007


  • Amyotrophic lateral sclerosis
  • Multidisciplinary clinic
  • Survival

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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