Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy

James A. McCubrey, Melissa L. Sokolosky, Brian D. Lehmann, Jackson R. Taylor, Patrick M. Navolanic, William H. Chappell, Stephen L. Abrams, Kristin M. Stadelman, Ellis W T Wong, Negin Misaghian, Stefan Horn, Jörg Bäsecke, Massimo Libra, Franca Stivala, Giovanni Ligresti, Agostino Tafuri, Michele Milella, Marek Zarzycki, Andrzej Dzugaj, Francesca ChiariniCamilla Evangelisti, Alberto M. Martelli, David M. Terrian, Richard A. Franklin, Linda S. Steelman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Breast cancer is a common disease which affects women and men in the prime of their lives. Unfortunately there is no common magic bullet which can effectively cure all breast cancers. Breast cancer arises from many diverse genetic mechanisms. Frequently breast cancer becomes resistant to various therapies and residual, dormant, senescent, drug resistant breast cancer cells resume their growth and often metastasize to other sites. At this point, therapeutic options are limited and we desperately need more effective treatments. This chapter has focused on the key roles that the PI3K/PTEN/Akt/mTOR pathway plays in breast cancer drug resistance and induction of cellular sensecence. Furthermore, breast cancer cells which proliferate in response to this pathway may have an Achilles heel and are highly sensitive to mTOR inhibitors.

Original languageEnglish
Pages (from-to)113-135
Number of pages23
JournalAdvances in Enzyme Regulation
Volume48
Issue number1
DOIs
Publication statusPublished - 2008

Fingerprint

Drug Resistance
Cells
Breast Neoplasms
Phosphatidylinositol 3-Kinases
Pharmaceutical Preparations
Therapeutics
Magic
Growth

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy. / McCubrey, James A.; Sokolosky, Melissa L.; Lehmann, Brian D.; Taylor, Jackson R.; Navolanic, Patrick M.; Chappell, William H.; Abrams, Stephen L.; Stadelman, Kristin M.; Wong, Ellis W T; Misaghian, Negin; Horn, Stefan; Bäsecke, Jörg; Libra, Massimo; Stivala, Franca; Ligresti, Giovanni; Tafuri, Agostino; Milella, Michele; Zarzycki, Marek; Dzugaj, Andrzej; Chiarini, Francesca; Evangelisti, Camilla; Martelli, Alberto M.; Terrian, David M.; Franklin, Richard A.; Steelman, Linda S.

In: Advances in Enzyme Regulation, Vol. 48, No. 1, 2008, p. 113-135.

Research output: Contribution to journalArticle

McCubrey, JA, Sokolosky, ML, Lehmann, BD, Taylor, JR, Navolanic, PM, Chappell, WH, Abrams, SL, Stadelman, KM, Wong, EWT, Misaghian, N, Horn, S, Bäsecke, J, Libra, M, Stivala, F, Ligresti, G, Tafuri, A, Milella, M, Zarzycki, M, Dzugaj, A, Chiarini, F, Evangelisti, C, Martelli, AM, Terrian, DM, Franklin, RA & Steelman, LS 2008, 'Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy', Advances in Enzyme Regulation, vol. 48, no. 1, pp. 113-135. https://doi.org/10.1016/j.advenzreg.2008.02.006
McCubrey, James A. ; Sokolosky, Melissa L. ; Lehmann, Brian D. ; Taylor, Jackson R. ; Navolanic, Patrick M. ; Chappell, William H. ; Abrams, Stephen L. ; Stadelman, Kristin M. ; Wong, Ellis W T ; Misaghian, Negin ; Horn, Stefan ; Bäsecke, Jörg ; Libra, Massimo ; Stivala, Franca ; Ligresti, Giovanni ; Tafuri, Agostino ; Milella, Michele ; Zarzycki, Marek ; Dzugaj, Andrzej ; Chiarini, Francesca ; Evangelisti, Camilla ; Martelli, Alberto M. ; Terrian, David M. ; Franklin, Richard A. ; Steelman, Linda S. / Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy. In: Advances in Enzyme Regulation. 2008 ; Vol. 48, No. 1. pp. 113-135.
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