Alteration of chemotherapy (cisplatin and 5-FU) and radiotherapy in the management of advanced or recurrent head and neck cancer: a phase II study.

A. Grimaldi, M. Merlano, M. Benasso, G. Margarino, F. Scasso, R. Corvò, R. Rosso

Research output: Contribution to journalArticle

Abstract

Between July '84 and July '85, 20 patients with very advanced or relapsing carcinomas of the upper aerodigestive tract were treated with polychemotherapy (cisplatin 20 mg/m2 days 1 to 5, and 5-fluorouracil 200 mg/m2 days 1 to 5, q. 3 weeks), alternated with radiation (3 split courses, 20 Gy each). Toxicity was moderate and in particular, mucositis and other relevant side effects including leukopenia, thrombocytopenia and nausea, were rare. Antitumoral activity consisted of nine complete responses and six partial responses (75% objective responses). Our conclusions are that cisplatin and 5-FU can be alternated with radiation with acceptable toxicity. The treatment has shown interesting antitumoral activity. Its role in cancer management must be investigated with controlled clinical trials.

Original languageEnglish
Pages (from-to)356-359
Number of pages4
JournalChemioterapia
Volume5
Issue number5
Publication statusPublished - Oct 1986

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Head and Neck Neoplasms
Fluorouracil
Cisplatin
Radiotherapy
Radiation
Drug Therapy
Mucositis
Controlled Clinical Trials
Leukopenia
Combination Drug Therapy
Thrombocytopenia
Nausea
Carcinoma
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)

Cite this

Alteration of chemotherapy (cisplatin and 5-FU) and radiotherapy in the management of advanced or recurrent head and neck cancer : a phase II study. / Grimaldi, A.; Merlano, M.; Benasso, M.; Margarino, G.; Scasso, F.; Corvò, R.; Rosso, R.

In: Chemioterapia, Vol. 5, No. 5, 10.1986, p. 356-359.

Research output: Contribution to journalArticle

Grimaldi, A. ; Merlano, M. ; Benasso, M. ; Margarino, G. ; Scasso, F. ; Corvò, R. ; Rosso, R. / Alteration of chemotherapy (cisplatin and 5-FU) and radiotherapy in the management of advanced or recurrent head and neck cancer : a phase II study. In: Chemioterapia. 1986 ; Vol. 5, No. 5. pp. 356-359.
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