Alteration of cytolytic and proliferative responsiveness of peripheral blood mononuclear cells from cluster headache patients to Interleukin-2

G. Stirparo, P. Martelletti, M. Giacovazzo, L. Frati, C. Rinaldi

Research output: Contribution to journalArticlepeer-review

Abstract

Cluster headache (CH) is a primary headache of unknown etiology and various immunological abnormalities have been found in these patients. In a previous paper a reduced activity of Natural Killer (NK) cells have been demonstrated in these patents. This study describes the effects of Interleukin-2 (IL-2) on the NK cell activity, on the IL-2 receptor (CD25) expression, and on the proliferative ability by peripheral blood mononuclear cells (PBMC) collected from CH patients. We found that IL-2 was highly effective in the restoration of the low NK activity found in CH patients; that IL-2 stimulated PBMC from patients evidenced a proportion of CD25 positive cells lower than that found in PBMC from control subjects and finally, that IL-2 was not able to increase the low proliferative ability of PBMC from CH patients. These results provide an additional evidence of the alteration of immunological status in patients affected by CH.

Original languageEnglish
Pages (from-to)159-168
Number of pages10
JournalInternational Journal of Immunopathology and Pharmacology
Volume6
Issue number3
Publication statusPublished - 1993

Keywords

  • CD25 antigen
  • Interleukin 2
  • Natural Killer
  • proliferation

ASJC Scopus subject areas

  • Pharmacology

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