Alteration of peripheral markers of copper homeostasis in Alzheimer's disease patients: Implications in aetiology and therapy

Luisa Rossi, R. Squitti, L. Calabrese, G. Rotilio, P. M. Rossini

Research output: Contribution to journalArticle

Abstract

Alzheimer's disease represents a growing health problem because of the ongoing increase in life expectancy. Therefore understanding the molecular alterations responsible for neurodegeneration has become imperative in order to develop efficient strategies for the therapy. Mounting evidence suggests that the essential metal ion copper is intriguingly connected with the established molecular markers of Alzheimer's disease and that copper homeostasis is disturbed in affected individuals, leading to oxidative stress and neurodegeneration. This review summarizes the mechanisms of copper trafficking in cells and describes the relationship between copper, the amyloid precursor protein and β-amyloid. Since one of the main goals of the research on Alzheimer's disease is the identification of blood markers to aid diagnosis and monitor the effects of therapeutic approaches, the results obtained in a series of studies on copper in the blood of Alzheimer's disease patients recently carried out in our laboratories are described.

Original languageEnglish
Pages (from-to)408-417
Number of pages10
JournalJournal of Nutrition, Health and Aging
Volume11
Issue number5
Publication statusPublished - Sep 2007

Keywords

  • Alzheimer's disease
  • Copper
  • Neurodegeneration
  • Oxidative stress
  • Serum

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Ageing
  • Endocrinology
  • Food Science

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