Alteration of polyunsaturated fatty acid pattern of plasma phospholipids and antioxidants in cervical HPV infection and neoplasia

Maurizio Pozzi, Barbara Villaccio, Mauro Picardo, Emanuela Camera, Aldo Di Carlo

Research output: Contribution to journalArticle

Abstract

The complex interactions between host immunity and infectious diseases have been documented in literature and they play a role in virus infection. Many clinical-experimental reports have stressed the importance of homeostasis of cell membranes and of the 'cell healthy indicators', namely polyunsaturated fatty acids and antioxidants in HIV infection. Today's increased incidence of heterosexual transmission of HIV has showed a strict correlation between HIV and HPV infection. According to some studies, positive HPV subjects have 40-200 times a greater risk of becoming HIV- positive. We have evaluated in 40 women with HPV infection the plasma levels of polyunsaturated fatty acids of phospholipids and vitamin E, determined by GC-MS methods, and the erythrocyte glutathione peroxidase activity (GHS-Px) by spectrophotometric techniques. The alteration of these parameters were correlated with the progression of the infection, i.e. the appearance of dysplastic or neoplastic pathologies on the uterine cervix. The differences were statistically significant (p

Original languageEnglish
Pages (from-to)1243-1247
Number of pages5
JournalOncology Reports
Volume4
Issue number6
Publication statusPublished - Nov 1997

Keywords

  • Antioxidants
  • Cervical neoplasia
  • Plasma phospholipids
  • Polyunsaturated fatty acid

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Alteration of polyunsaturated fatty acid pattern of plasma phospholipids and antioxidants in cervical HPV infection and neoplasia'. Together they form a unique fingerprint.

  • Cite this