Abstract
Peripheral blood lymphocytes of 8 tetanus patients have been studied with monoclonal antibodies and flow cytometry. During the progression of the disease OKT3 + and Leu7+ cells undergo significative daily variations and OKT4+ cells become the majority of peripheral blood T cells. In two patients is present a severe T lymphopenia and one of these subjects presented a more prolonged disease compared to the other ones. B cells are greatly increased after 10-12 days. Two possibilities could be considered of lymphocytes producing also an expansion of OKT4+ cells containing a helper population; secondly the observed alterations of lymphocytes subsets are not due to the infection itself but rather to the massive administration of specific immunoglobulins to these patients.
Original language | English |
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Pages (from-to) | 196-200 |
Number of pages | 5 |
Journal | Bollettino dell'Istituto Sieroterapico Milanese |
Volume | 63 |
Issue number | 3 |
Publication status | Published - 1984 |
ASJC Scopus subject areas
- Immunology