Alteration of T cell subsets during tetanus infection treated with high doses of specific immunoglobulins

P. de Paoli, S. Battistin, M. Reitano, C. Castiglia, G. F. Santini

Research output: Contribution to journalArticlepeer-review

Abstract

Peripheral blood lymphocytes of 8 tetanus patients have been studied with monoclonal antibodies and flow cytometry. During the progression of the disease OKT3 + and Leu7+ cells undergo significative daily variations and OKT4+ cells become the majority of peripheral blood T cells. In two patients is present a severe T lymphopenia and one of these subjects presented a more prolonged disease compared to the other ones. B cells are greatly increased after 10-12 days. Two possibilities could be considered of lymphocytes producing also an expansion of OKT4+ cells containing a helper population; secondly the observed alterations of lymphocytes subsets are not due to the infection itself but rather to the massive administration of specific immunoglobulins to these patients.

Original languageEnglish
Pages (from-to)196-200
Number of pages5
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume63
Issue number3
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Alteration of T cell subsets during tetanus infection treated with high doses of specific immunoglobulins'. Together they form a unique fingerprint.

Cite this