Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis

Daniela Fenoglio, Florinda Battaglia, Alessia Parodi, Silvia Stringara, Simone Negrini, Nicoletta Panico, Marta Rizzi, Francesca Kalli, Giuseppina Conteduca, Massimo Ghio, Raffaele De Palma, Francesco Indiveri, Gilberto Filaci

Research output: Contribution to journalArticle

Abstract

Aim of the study has been to understand the relationship between TH17 and Treg cell subsets in patients affected with systemic sclerosis (SSc). Phenotypes and functions of Th17 and Treg cell subsets were analyzed in a series of 36 SSc patients. Th17 cell concentration in the peripheral blood was found to be increased in SSc patients with respect to healthy controls independently from type or stage of disease. After PBMC stimulation with a polyclonal stimulus or Candida albicans antigens the frequency of Th17 T cell clones was significantly higher in SSc patients with respect to controls suggesting the skewing of immune response in SSc patients toward Th17 cell generation/expansion. Concerning the Treg compartment, both CD4+CD25+ and CD8+CD28- Treg subsets showed quantitative and qualitative alteration in the peripheral blood of SSc patients. Collectively, these data highlight the existence of an imbalanced ratio between Th17 and Treg cell subsets in SSc patients.

Original languageEnglish
Pages (from-to)249-257
Number of pages9
JournalClinical Immunology
Volume139
Issue number3
DOIs
Publication statusPublished - Jun 2011

Keywords

  • Systemic sclerosis
  • Th17 cells
  • Treg

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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    Fenoglio, D., Battaglia, F., Parodi, A., Stringara, S., Negrini, S., Panico, N., Rizzi, M., Kalli, F., Conteduca, G., Ghio, M., De Palma, R., Indiveri, F., & Filaci, G. (2011). Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis. Clinical Immunology, 139(3), 249-257. https://doi.org/10.1016/j.clim.2011.01.013