Alteration of the passive electrical properties of lymphocyte membranes induced by GM1 and GM3 glycolipids

C. Cametti, F. De Luca, A. D'Ilario, M. A. Macrì, B. Maraviglia, F. Bordi, L. Lenti, R. Misasi, M. Sorice

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The electrical conductivity of normal human lymphocyte suspensions has been measured in the frequency range from 10 kHz to 100 MHz, where a well-pronounced conductivity dispersion occurs, caused by the surface polarization at the interface between the cell membrane and the extracellular solution. We have investigated the alteration of the passive electrical properties of the cytoplasmic cell membrane induced by two different gangliosides (GM1 and GM3) inserted, at various concentrations, into the outer leaflet of membrane double layer. The alterations observed in the dielectric parameters (the membrane conductivity and the membrane permittivity) derived on the basis of a 'double-shell' model, result in an overall increase of the ion permeation across the membrane and an enhanced polarizability of its hydrophilic region for both gangliosides investigated. The relevance of these alterations is discussed.

Original languageEnglish
Pages (from-to)197-203
Number of pages7
JournalBBA - Biomembranes
Volume1111
Issue number2
DOIs
Publication statusPublished - Nov 9 1992

Fingerprint

Lymphocytes
Glycolipids
Electric properties
Membranes
Cell Membrane
Cell membranes
G(M3) Ganglioside
G(M1) Ganglioside
Electric Conductivity
Gangliosides
Permeation
Suspensions
Permittivity
Ions
Polarization

Keywords

  • Conductance
  • Ganglioside
  • GM1
  • GM3
  • Lymphocyte
  • Membrane

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology

Cite this

Cametti, C., De Luca, F., D'Ilario, A., Macrì, M. A., Maraviglia, B., Bordi, F., ... Sorice, M. (1992). Alteration of the passive electrical properties of lymphocyte membranes induced by GM1 and GM3 glycolipids. BBA - Biomembranes, 1111(2), 197-203. https://doi.org/10.1016/0005-2736(92)90311-9

Alteration of the passive electrical properties of lymphocyte membranes induced by GM1 and GM3 glycolipids. / Cametti, C.; De Luca, F.; D'Ilario, A.; Macrì, M. A.; Maraviglia, B.; Bordi, F.; Lenti, L.; Misasi, R.; Sorice, M.

In: BBA - Biomembranes, Vol. 1111, No. 2, 09.11.1992, p. 197-203.

Research output: Contribution to journalArticle

Cametti, C, De Luca, F, D'Ilario, A, Macrì, MA, Maraviglia, B, Bordi, F, Lenti, L, Misasi, R & Sorice, M 1992, 'Alteration of the passive electrical properties of lymphocyte membranes induced by GM1 and GM3 glycolipids', BBA - Biomembranes, vol. 1111, no. 2, pp. 197-203. https://doi.org/10.1016/0005-2736(92)90311-9
Cametti, C. ; De Luca, F. ; D'Ilario, A. ; Macrì, M. A. ; Maraviglia, B. ; Bordi, F. ; Lenti, L. ; Misasi, R. ; Sorice, M. / Alteration of the passive electrical properties of lymphocyte membranes induced by GM1 and GM3 glycolipids. In: BBA - Biomembranes. 1992 ; Vol. 1111, No. 2. pp. 197-203.
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