Abstract
In chronic heart failure substantial and characteristic changes occur in the function of the adrenergic nervous system. Studies in isolated left ventricular muscle and in single cardiomyocytes from experimental models of aging and, recently, from humans show an age-related reduced contractile response to β-adrenoceptor stimulation. 'β-adrenoceptor desensitization' is thought to be a general and common mechanism to explain the age- and heart failure-related decrease in β-adrenoceptor response. The aim of this review is to compare alterations in β-adrenoceptor mechanisms in physiological cardiovascular aging and chronic heart failure. From an analysis of the overall data on the role of aging in β-adrenoceptor regulation in human and animal hearts, it is possible to conclude that the reduced response to β- agonists is common to all species and all cardiac tissues. Moreover, the age- related changes are limited to β-adrenoceptor-G-protein (s)-adenytyl cyclase system abnormalities, while the type and level of abnormalities change with species and tissues. The modifications shown in the aging heart are not very different from some observed in heart failure. In particular, both in aged and failing hearts we may see that the decrease in β-adrenoceptor responsiveness is related to changes in G-protein function.
| Original language | English |
|---|---|
| Pages (from-to) | 391-403 |
| Number of pages | 13 |
| Journal | Aging clinical and experimental research |
| Volume | 9 |
| Issue number | 6 |
| Publication status | Published - Dec 1997 |
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Keywords
- β-adrenergic receptor
- β-adrenoceptor desensitization
- Aging
- G-protein.
- Heart failure
ASJC Scopus subject areas
- Ageing
- Geriatrics and Gerontology
Cite this
Alterations in β-adrenoceptor mechanisms in the aging heart. Relationship with heart failure. / Ferrara, N.; Davia, K.; Abete, P.; Rengo, F.; Harding, S. E.
In: Aging clinical and experimental research, Vol. 9, No. 6, 12.1997, p. 391-403.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alterations in β-adrenoceptor mechanisms in the aging heart. Relationship with heart failure
AU - Ferrara, N.
AU - Davia, K.
AU - Abete, P.
AU - Rengo, F.
AU - Harding, S. E.
PY - 1997/12
Y1 - 1997/12
N2 - In chronic heart failure substantial and characteristic changes occur in the function of the adrenergic nervous system. Studies in isolated left ventricular muscle and in single cardiomyocytes from experimental models of aging and, recently, from humans show an age-related reduced contractile response to β-adrenoceptor stimulation. 'β-adrenoceptor desensitization' is thought to be a general and common mechanism to explain the age- and heart failure-related decrease in β-adrenoceptor response. The aim of this review is to compare alterations in β-adrenoceptor mechanisms in physiological cardiovascular aging and chronic heart failure. From an analysis of the overall data on the role of aging in β-adrenoceptor regulation in human and animal hearts, it is possible to conclude that the reduced response to β- agonists is common to all species and all cardiac tissues. Moreover, the age- related changes are limited to β-adrenoceptor-G-protein (s)-adenytyl cyclase system abnormalities, while the type and level of abnormalities change with species and tissues. The modifications shown in the aging heart are not very different from some observed in heart failure. In particular, both in aged and failing hearts we may see that the decrease in β-adrenoceptor responsiveness is related to changes in G-protein function.
AB - In chronic heart failure substantial and characteristic changes occur in the function of the adrenergic nervous system. Studies in isolated left ventricular muscle and in single cardiomyocytes from experimental models of aging and, recently, from humans show an age-related reduced contractile response to β-adrenoceptor stimulation. 'β-adrenoceptor desensitization' is thought to be a general and common mechanism to explain the age- and heart failure-related decrease in β-adrenoceptor response. The aim of this review is to compare alterations in β-adrenoceptor mechanisms in physiological cardiovascular aging and chronic heart failure. From an analysis of the overall data on the role of aging in β-adrenoceptor regulation in human and animal hearts, it is possible to conclude that the reduced response to β- agonists is common to all species and all cardiac tissues. Moreover, the age- related changes are limited to β-adrenoceptor-G-protein (s)-adenytyl cyclase system abnormalities, while the type and level of abnormalities change with species and tissues. The modifications shown in the aging heart are not very different from some observed in heart failure. In particular, both in aged and failing hearts we may see that the decrease in β-adrenoceptor responsiveness is related to changes in G-protein function.
KW - β-adrenergic receptor
KW - β-adrenoceptor desensitization
KW - Aging
KW - G-protein.
KW - Heart failure
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M3 - Article
C2 - 9553617
AN - SCOPUS:0031426844
VL - 9
SP - 391
EP - 403
JO - Aging clinical and experimental research
JF - Aging clinical and experimental research
SN - 1594-0667
IS - 6
ER -