Alterations in NFκB/Rel family proteins in splenic T-cells from tumor-bearing mice and reversal following therapy

Paritosh Ghosh, Antonio Sica, Howard A. Young, Jianping Ye, José L. Franco, Robert H. Wiltrout, Dan L. Longo, Nancy R. Rice, Kristin L. Komschlies

Research output: Contribution to journalArticle

Abstract

It has recently been shown that T-cell signal transduction molecules are altered in tumor-bearing mice. We have examined the expression of NFκB/Rel family proteins in T-cells from mice bearing Renca, a murine renal carcinoma. T-cells from Renca-bearing mice expressed undetectable levels of nuclear c-Rel, NFκB 65, and p50; however two shorter forms of p50 (p48 and p46), truncated at the NH2-terminus, were present exclusively in the nucleus and were able to bind DNA. These T-cells have reduced expression of γ-interferon mRNA. In mice successfully treated with flavone 8-acetic acid and recombinant human interleukin 2, the T-cells expressed normal levels of all three nuclear NFκB/Rel proteins. These results suggest that alterations in transcription factors may accompany changes in signal transduction molecules in T-cells from tumor-bearing animals; however, the changes are reversed with successful biological therapy.

Original languageEnglish
Pages (from-to)2969-2972
Number of pages4
JournalCancer Research
Volume54
Issue number11
Publication statusPublished - Jun 1 1994

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Ghosh, P., Sica, A., Young, H. A., Ye, J., Franco, J. L., Wiltrout, R. H., Longo, D. L., Rice, N. R., & Komschlies, K. L. (1994). Alterations in NFκB/Rel family proteins in splenic T-cells from tumor-bearing mice and reversal following therapy. Cancer Research, 54(11), 2969-2972.