Abstract
The development of cancer is a cellular process that reflects and is partly driven by alterations in cell determination. Mutations in various molecules responsible for cell determination have been identified as being oncogenic, but little is known about the involvement of normal cell fate- determining mechanisms in the oncogenic process. The Notch pathway defines an evolutionarily conserved, general cell interaction mechanism that controls fundamental aspects of cell determination during vertebrate and invertebrate development. We have explored the involvement of the human Notch pathway in human cervical tissues, which define a cellular environment where cell fate changes take place and where neoplastic conditions have been well characterized. Our evidence suggests that Notch expression is associated with cell populations that are undergoing cell fate changes and that Notch activity can be used to monitor cell fate abnormalities in cervical as well as other epithelial neoplasias.
| Original language | English |
|---|---|
| Pages (from-to) | 6414-6418 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 92 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - Jul 3 1995 |
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ASJC Scopus subject areas
- Genetics
- General
Cite this
Alterations in Notch signaling in neoplastic lesions of the human cervix. / Zagouras, Panayiotis; Stifani, Stefano; Blaumueller, Christine M.; Carcangiu, Maria L.; Artavanis-Tsakonas, Spyros.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, No. 14, 03.07.1995, p. 6414-6418.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alterations in Notch signaling in neoplastic lesions of the human cervix
AU - Zagouras, Panayiotis
AU - Stifani, Stefano
AU - Blaumueller, Christine M.
AU - Carcangiu, Maria L.
AU - Artavanis-Tsakonas, Spyros
PY - 1995/7/3
Y1 - 1995/7/3
N2 - The development of cancer is a cellular process that reflects and is partly driven by alterations in cell determination. Mutations in various molecules responsible for cell determination have been identified as being oncogenic, but little is known about the involvement of normal cell fate- determining mechanisms in the oncogenic process. The Notch pathway defines an evolutionarily conserved, general cell interaction mechanism that controls fundamental aspects of cell determination during vertebrate and invertebrate development. We have explored the involvement of the human Notch pathway in human cervical tissues, which define a cellular environment where cell fate changes take place and where neoplastic conditions have been well characterized. Our evidence suggests that Notch expression is associated with cell populations that are undergoing cell fate changes and that Notch activity can be used to monitor cell fate abnormalities in cervical as well as other epithelial neoplasias.
AB - The development of cancer is a cellular process that reflects and is partly driven by alterations in cell determination. Mutations in various molecules responsible for cell determination have been identified as being oncogenic, but little is known about the involvement of normal cell fate- determining mechanisms in the oncogenic process. The Notch pathway defines an evolutionarily conserved, general cell interaction mechanism that controls fundamental aspects of cell determination during vertebrate and invertebrate development. We have explored the involvement of the human Notch pathway in human cervical tissues, which define a cellular environment where cell fate changes take place and where neoplastic conditions have been well characterized. Our evidence suggests that Notch expression is associated with cell populations that are undergoing cell fate changes and that Notch activity can be used to monitor cell fate abnormalities in cervical as well as other epithelial neoplasias.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029078323&partnerID=8YFLogxK
U2 - 10.1073/pnas.92.14.6414
DO - 10.1073/pnas.92.14.6414
M3 - Article
C2 - 7604005
AN - SCOPUS:0029078323
VL - 92
SP - 6414
EP - 6418
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 14
ER -