Alterations in Notch signaling in neoplastic lesions of the human cervix

Panayiotis Zagouras, Stefano Stifani, Christine M. Blaumueller, Maria L. Carcangiu, Spyros Artavanis-Tsakonas

Research output: Contribution to journalArticle

Abstract

The development of cancer is a cellular process that reflects and is partly driven by alterations in cell determination. Mutations in various molecules responsible for cell determination have been identified as being oncogenic, but little is known about the involvement of normal cell fate- determining mechanisms in the oncogenic process. The Notch pathway defines an evolutionarily conserved, general cell interaction mechanism that controls fundamental aspects of cell determination during vertebrate and invertebrate development. We have explored the involvement of the human Notch pathway in human cervical tissues, which define a cellular environment where cell fate changes take place and where neoplastic conditions have been well characterized. Our evidence suggests that Notch expression is associated with cell populations that are undergoing cell fate changes and that Notch activity can be used to monitor cell fate abnormalities in cervical as well as other epithelial neoplasias.

Original languageEnglish
Pages (from-to)6414-6418
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume92
Issue number14
DOIs
Publication statusPublished - Jul 3 1995

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ASJC Scopus subject areas

  • Genetics
  • General

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