Alterations in surface morphology of Candida albicans produced by rilopirox: A scanning electron microscopy study

P. C. Braga, S. Maci, M. Dal Sasso, G. Piatti, M. Bohn

Research output: Contribution to journalArticlepeer-review

Abstract

The topological changes produced in Candida albicans cells by incubation in vitro with rilopirox have been investigated by scanning electron microscopy. Rilopirox is a new hydroxypyridone compound with fungicidal activity and the effects of 1 x MIC (2.9 μg/ml) and 4 x MIC (11.6 μg/ml) after 1, 12, 24 hours of incubation were evaluated. The morphological alterations produced by rilopirox are round shapes, collapsed cells, surface folds, clusters, holes and thorn-like extrusion. The effects of rilopirox are already evident at 1 x MIC and after 1 h but their frequency and severity are correlated with the time of incubation and the MIC.

Original languageEnglish
Pages (from-to)519-524
Number of pages6
JournalJournal of Chemotherapy
Volume7
Issue number6
Publication statusPublished - 1995

Keywords

  • Candida albicans
  • rilopirox
  • scanning electron microscopy
  • surface morphology

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)

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