Alterations in the autonomic control of heart rate variability in patients with anorexia or bulimia nervosa: Correlations between sympathovagal activity, clinical features, and leptin levels

G. Murialdo, M. Casu, M. Falchero, A. Brugnolo, V. Patrone, P. F. Cerro, P. Ameri, G. Andraghetti, L. Briatore, F. Copello, R. Cordera, G. Rodriguez, A. M. Ferro

Research output: Contribution to journalArticle

Abstract

Changes in body composition, hormone secretions, and heart function with increased risk of sudden death occur in eating disorders. In this observational clinical study, we evaluated sympathovagal modulation of heart rate variability (HRV) and cardiovascular changes in response to lying-to-standing in patients with anorexia (AN) or bulimia nervosa (BN) to analyze: a) differences in autonomic activity between AN, BN, and healthy subjects; b) relationships between autonomic and cardiovascular parameters, clinical data and leptin levels in patients with eating disorders. HRV, assessed by power spectral analysis of R-R intervals, blood pressure (BP) and heart rate (HR) were studied by tilt-table test in 34 patients with AN, 16 with BN and 30 healthy controls. Autonomic and cardiovascular findings were correlated with clinical data, and serum leptin levels. Leptin levels were lowered in AN vs BN and healthy subjects (p

Original languageEnglish
Pages (from-to)356-362
Number of pages7
JournalJournal of Endocrinological Investigation
Volume30
Issue number5
Publication statusPublished - May 2007

Keywords

  • Anorexia nervosa
  • Bulimia nervosa
  • Heart rate variability
  • Leptin
  • Sympathovagal activity

ASJC Scopus subject areas

  • Endocrinology

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    Murialdo, G., Casu, M., Falchero, M., Brugnolo, A., Patrone, V., Cerro, P. F., Ameri, P., Andraghetti, G., Briatore, L., Copello, F., Cordera, R., Rodriguez, G., & Ferro, A. M. (2007). Alterations in the autonomic control of heart rate variability in patients with anorexia or bulimia nervosa: Correlations between sympathovagal activity, clinical features, and leptin levels. Journal of Endocrinological Investigation, 30(5), 356-362.