Alterations in urokinase levels and impairment in fibrinolytic system in non insulin dependent diabetes mellitus (niddm)

K. Krekora, L. Iacoviello, D. De Lucia, C. Amore, G. Dooijewaard, A. Consoli, F. Capani, M. B. Donati

Research output: Contribution to journalArticle

Abstract

"Angela Valenti" Laboratory of Thrombosis Pharmacology. Istituto Mario Negri, Consorzio Mario Negri Sud, 66030 S. Maria Imbaro, 1 Institute of General Pathology and Oncology, II University ot Naples, Italy, 2 Gaubius Laboratory, TNO-PG, Leiden, The Netherlands and 3 Facolta di Medicina, Université di Chieti, Italy. NIDDM has been associated with an increased incidence of atherothrombotic complications. Abnormalities in the haemostatic system contribute at least in part to the development of atherothrombosis. In particular an increase in fibrinogen levels and a decrease in fibrinolytic potential, mainly due to tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) alterations have been described. However, no informations are presently available on urokinase (UK) levels in NIDDM patients. To analyze the fibrinolytic system in NIDDM, UK activity (BIA = scuPA + tcuPA), UK antigen (ELISA = scuPA + tcuPA + uPA.Inh complex), fibrinogen, t-PA and PAI-1 were studied in 58 patients (22 women and 36 men; age 63±10) with NIDDM. In NIDDM patients there was no increase in UK both activity and antigen after venous stasis. However, the levels of UK activity (1.8±0.6 vs. 2.2±0.6 ng/ml p

Original languageEnglish
Pages (from-to)23
Number of pages1
JournalFibrinolysis
Volume10
Issue numberSUPPL. 3
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Hematology

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