Alterations in vasopressin regulation in Alzheimer's disease

Guido Norbiato, Maurizio Bevilacqua, Francesco Carella, Enrica Chebat, Umberto Raggi, Pierluigi Bertora, Maria Pia Grassi, Alfonso Mangoni

Research output: Contribution to journalArticle

Abstract

A decreased concentration of vasopressin (AVP) in the plasma of patients with Alzheimer's disease has been shown recently and suggests damage to hypothalamic neurosecretory cells. To verify this, osmolar and hypotension (sodium nitroprusside) stimulations on AVP release were applied. The effect of metoclopramide, a powerful stimulator of AVP, was also assessed. Patients with Alzheimer's disease released AVP normally after hypotension. However, AVP response to osmotic stimulation was altered in eight out of 10 patients, owing to low osmoreceptor sensitivity and/or high threshold. Metoclopramide increased AVP in controls but not in patients. Normal AVP response to hypotension in patients with Alzheimer's disease makes it unlikely that there is a significant anatomical loss or damage of hypothalamic neurosecretory cells. Alterations in osmoreceptor function and AVP unresponsiveness to metoclopramide point to damage in the control of AVP release in Alzheimer's disease.

Original languageEnglish
Pages (from-to)903-908
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume51
Issue number7
DOIs
Publication statusPublished - 1988

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Vasopressins
Alzheimer Disease
Metoclopramide
Hypotension
Nitroprusside

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Norbiato, G., Bevilacqua, M., Carella, F., Chebat, E., Raggi, U., Bertora, P., ... Mangoni, A. (1988). Alterations in vasopressin regulation in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 51(7), 903-908. https://doi.org/10.1136/jnnp.51.7.903

Alterations in vasopressin regulation in Alzheimer's disease. / Norbiato, Guido; Bevilacqua, Maurizio; Carella, Francesco; Chebat, Enrica; Raggi, Umberto; Bertora, Pierluigi; Grassi, Maria Pia; Mangoni, Alfonso.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 51, No. 7, 1988, p. 903-908.

Research output: Contribution to journalArticle

Norbiato, G, Bevilacqua, M, Carella, F, Chebat, E, Raggi, U, Bertora, P, Grassi, MP & Mangoni, A 1988, 'Alterations in vasopressin regulation in Alzheimer's disease', Journal of Neurology, Neurosurgery and Psychiatry, vol. 51, no. 7, pp. 903-908. https://doi.org/10.1136/jnnp.51.7.903
Norbiato, Guido ; Bevilacqua, Maurizio ; Carella, Francesco ; Chebat, Enrica ; Raggi, Umberto ; Bertora, Pierluigi ; Grassi, Maria Pia ; Mangoni, Alfonso. / Alterations in vasopressin regulation in Alzheimer's disease. In: Journal of Neurology, Neurosurgery and Psychiatry. 1988 ; Vol. 51, No. 7. pp. 903-908.
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