TY - JOUR
T1 - Alterations of cerebral blood flow and antiphospholipid antibodies in patients with systemic lupus erythematosus
AU - Postiglione, A.
AU - De Chiara, S.
AU - Soricelli, A.
AU - Oriente, A.
AU - Ruocco, A.
AU - Spadaro, G.
AU - Montefusco, S.
AU - Marone, G.
AU - Genovese, A.
PY - 1998/4
Y1 - 1998/4
N2 - Twenty-two patients with systemic lupus erythematosus and 13 healthy controls were included in a cerebral blood flow study and underwent brain-dedicated sin gle-photon emission computed tomography using (99m)technetium-d, 1-hexamethylpropylene amine oxime together with a brain computed tomography scan. Plasma levels of antiphospholipid anitibodies (lupus anticoagulant and anticardiolipin IgM and IgG antibodies) were- also determined. Brain computed tomography showed: signs of focal cerebral ischemia in 4 patients (18%), whereas cerebral blood flow by single-photon emission computed tomography was abnormal in 13 of 22 patients (59%), who showed bilateral or monolateral hypoperfusion in the temporo-parietal regions. Patients with abnormal cerebral blood flow had a longer duration of disease than those with normal blood flow (8.9 ± 1.9 years vs. 5.3 ± 1.5 years, P
AB - Twenty-two patients with systemic lupus erythematosus and 13 healthy controls were included in a cerebral blood flow study and underwent brain-dedicated sin gle-photon emission computed tomography using (99m)technetium-d, 1-hexamethylpropylene amine oxime together with a brain computed tomography scan. Plasma levels of antiphospholipid anitibodies (lupus anticoagulant and anticardiolipin IgM and IgG antibodies) were- also determined. Brain computed tomography showed: signs of focal cerebral ischemia in 4 patients (18%), whereas cerebral blood flow by single-photon emission computed tomography was abnormal in 13 of 22 patients (59%), who showed bilateral or monolateral hypoperfusion in the temporo-parietal regions. Patients with abnormal cerebral blood flow had a longer duration of disease than those with normal blood flow (8.9 ± 1.9 years vs. 5.3 ± 1.5 years, P
KW - Antiphospholipid antibodies
KW - Cerebral blood flow
KW - Systemic lupus erythematosus
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U2 - 10.1007/s005990050015
DO - 10.1007/s005990050015
M3 - Article
C2 - 9594361
AN - SCOPUS:0031960501
VL - 28
SP - 34
EP - 38
JO - Ricerca in Clinica e in Laboratorio
JF - Ricerca in Clinica e in Laboratorio
SN - 0940-5437
IS - 1
ER -