Alterations of cerebral blood flow and antiphospholipid antibodies in patients with systemic lupus erythematosus

A. Postiglione, S. De Chiara, A. Soricelli, A. Oriente, A. Ruocco, G. Spadaro, S. Montefusco, G. Marone, A. Genovese

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Twenty-two patients with systemic lupus erythematosus and 13 healthy controls were included in a cerebral blood flow study and underwent brain-dedicated sin gle-photon emission computed tomography using (99m)technetium-d, 1-hexamethylpropylene amine oxime together with a brain computed tomography scan. Plasma levels of antiphospholipid anitibodies (lupus anticoagulant and anticardiolipin IgM and IgG antibodies) were- also determined. Brain computed tomography showed: signs of focal cerebral ischemia in 4 patients (18%), whereas cerebral blood flow by single-photon emission computed tomography was abnormal in 13 of 22 patients (59%), who showed bilateral or monolateral hypoperfusion in the temporo-parietal regions. Patients with abnormal cerebral blood flow had a longer duration of disease than those with normal blood flow (8.9 ± 1.9 years vs. 5.3 ± 1.5 years, P

Original languageEnglish
Pages (from-to)34-38
Number of pages5
JournalInternational Journal of Clinical & Laboratory Research
Volume28
Issue number1
DOIs
Publication statusPublished - Apr 1998

Fingerprint

Cerebrovascular Circulation
Antiphospholipid Antibodies
Systemic Lupus Erythematosus
Blood
Tomography
Brain
Emission-Computed Tomography
Single photon emission computed tomography
Lupus Coagulation Inhibitor
Parietal Lobe
Oximes
Technetium
Single-Photon Emission-Computed Tomography
Brain Ischemia
Photons
Amines
Immunoglobulin M
Immunoglobulin G
Plasmas
Antibodies

Keywords

  • Antiphospholipid antibodies
  • Cerebral blood flow
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Alterations of cerebral blood flow and antiphospholipid antibodies in patients with systemic lupus erythematosus. / Postiglione, A.; De Chiara, S.; Soricelli, A.; Oriente, A.; Ruocco, A.; Spadaro, G.; Montefusco, S.; Marone, G.; Genovese, A.

In: International Journal of Clinical & Laboratory Research, Vol. 28, No. 1, 04.1998, p. 34-38.

Research output: Contribution to journalArticle

Postiglione, A. ; De Chiara, S. ; Soricelli, A. ; Oriente, A. ; Ruocco, A. ; Spadaro, G. ; Montefusco, S. ; Marone, G. ; Genovese, A. / Alterations of cerebral blood flow and antiphospholipid antibodies in patients with systemic lupus erythematosus. In: International Journal of Clinical & Laboratory Research. 1998 ; Vol. 28, No. 1. pp. 34-38.
@article{adad0d2619504e4f92a4a8c7aff51832,
title = "Alterations of cerebral blood flow and antiphospholipid antibodies in patients with systemic lupus erythematosus",
abstract = "Twenty-two patients with systemic lupus erythematosus and 13 healthy controls were included in a cerebral blood flow study and underwent brain-dedicated sin gle-photon emission computed tomography using (99m)technetium-d, 1-hexamethylpropylene amine oxime together with a brain computed tomography scan. Plasma levels of antiphospholipid anitibodies (lupus anticoagulant and anticardiolipin IgM and IgG antibodies) were- also determined. Brain computed tomography showed: signs of focal cerebral ischemia in 4 patients (18{\%}), whereas cerebral blood flow by single-photon emission computed tomography was abnormal in 13 of 22 patients (59{\%}), who showed bilateral or monolateral hypoperfusion in the temporo-parietal regions. Patients with abnormal cerebral blood flow had a longer duration of disease than those with normal blood flow (8.9 ± 1.9 years vs. 5.3 ± 1.5 years, P",
keywords = "Antiphospholipid antibodies, Cerebral blood flow, Systemic lupus erythematosus",
author = "A. Postiglione and {De Chiara}, S. and A. Soricelli and A. Oriente and A. Ruocco and G. Spadaro and S. Montefusco and G. Marone and A. Genovese",
year = "1998",
month = "4",
doi = "10.1007/s005990050015",
language = "English",
volume = "28",
pages = "34--38",
journal = "Ricerca in Clinica e in Laboratorio",
issn = "0940-5437",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Alterations of cerebral blood flow and antiphospholipid antibodies in patients with systemic lupus erythematosus

AU - Postiglione, A.

AU - De Chiara, S.

AU - Soricelli, A.

AU - Oriente, A.

AU - Ruocco, A.

AU - Spadaro, G.

AU - Montefusco, S.

AU - Marone, G.

AU - Genovese, A.

PY - 1998/4

Y1 - 1998/4

N2 - Twenty-two patients with systemic lupus erythematosus and 13 healthy controls were included in a cerebral blood flow study and underwent brain-dedicated sin gle-photon emission computed tomography using (99m)technetium-d, 1-hexamethylpropylene amine oxime together with a brain computed tomography scan. Plasma levels of antiphospholipid anitibodies (lupus anticoagulant and anticardiolipin IgM and IgG antibodies) were- also determined. Brain computed tomography showed: signs of focal cerebral ischemia in 4 patients (18%), whereas cerebral blood flow by single-photon emission computed tomography was abnormal in 13 of 22 patients (59%), who showed bilateral or monolateral hypoperfusion in the temporo-parietal regions. Patients with abnormal cerebral blood flow had a longer duration of disease than those with normal blood flow (8.9 ± 1.9 years vs. 5.3 ± 1.5 years, P

AB - Twenty-two patients with systemic lupus erythematosus and 13 healthy controls were included in a cerebral blood flow study and underwent brain-dedicated sin gle-photon emission computed tomography using (99m)technetium-d, 1-hexamethylpropylene amine oxime together with a brain computed tomography scan. Plasma levels of antiphospholipid anitibodies (lupus anticoagulant and anticardiolipin IgM and IgG antibodies) were- also determined. Brain computed tomography showed: signs of focal cerebral ischemia in 4 patients (18%), whereas cerebral blood flow by single-photon emission computed tomography was abnormal in 13 of 22 patients (59%), who showed bilateral or monolateral hypoperfusion in the temporo-parietal regions. Patients with abnormal cerebral blood flow had a longer duration of disease than those with normal blood flow (8.9 ± 1.9 years vs. 5.3 ± 1.5 years, P

KW - Antiphospholipid antibodies

KW - Cerebral blood flow

KW - Systemic lupus erythematosus

UR - http://www.scopus.com/inward/record.url?scp=0031960501&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031960501&partnerID=8YFLogxK

U2 - 10.1007/s005990050015

DO - 10.1007/s005990050015

M3 - Article

VL - 28

SP - 34

EP - 38

JO - Ricerca in Clinica e in Laboratorio

JF - Ricerca in Clinica e in Laboratorio

SN - 0940-5437

IS - 1

ER -