Alterations of cerebral blood flow and antiphospholipid antibodies in patients with systemic lupus erythematosus

A. Postiglione, S. De Chiara, A. Soricelli, A. Oriente, A. Ruocco, G. Spadaro, S. Montefusco, G. Marone, A. Genovese

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty-two patients with systemic lupus erythematosus and 13 healthy controls were included in a cerebral blood flow study and underwent brain-dedicated sin gle-photon emission computed tomography using (99m)technetium-d, 1-hexamethylpropylene amine oxime together with a brain computed tomography scan. Plasma levels of antiphospholipid anitibodies (lupus anticoagulant and anticardiolipin IgM and IgG antibodies) were- also determined. Brain computed tomography showed: signs of focal cerebral ischemia in 4 patients (18%), whereas cerebral blood flow by single-photon emission computed tomography was abnormal in 13 of 22 patients (59%), who showed bilateral or monolateral hypoperfusion in the temporo-parietal regions. Patients with abnormal cerebral blood flow had a longer duration of disease than those with normal blood flow (8.9 ± 1.9 years vs. 5.3 ± 1.5 years, P

Original languageEnglish
Pages (from-to)34-38
Number of pages5
JournalInternational Journal of Clinical & Laboratory Research
Volume28
Issue number1
DOIs
Publication statusPublished - Apr 1998

Keywords

  • Antiphospholipid antibodies
  • Cerebral blood flow
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Clinical Biochemistry

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