Abstract
Twenty-two patients with systemic lupus erythematosus and 13 healthy controls were included in a cerebral blood flow study and underwent brain-dedicated sin gle-photon emission computed tomography using (99m)technetium-d, 1-hexamethylpropylene amine oxime together with a brain computed tomography scan. Plasma levels of antiphospholipid anitibodies (lupus anticoagulant and anticardiolipin IgM and IgG antibodies) were- also determined. Brain computed tomography showed: signs of focal cerebral ischemia in 4 patients (18%), whereas cerebral blood flow by single-photon emission computed tomography was abnormal in 13 of 22 patients (59%), who showed bilateral or monolateral hypoperfusion in the temporo-parietal regions. Patients with abnormal cerebral blood flow had a longer duration of disease than those with normal blood flow (8.9 ± 1.9 years vs. 5.3 ± 1.5 years, P
| Original language | English |
|---|---|
| Pages (from-to) | 34-38 |
| Number of pages | 5 |
| Journal | International Journal of Clinical & Laboratory Research |
| Volume | 28 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Apr 1998 |
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Keywords
- Antiphospholipid antibodies
- Cerebral blood flow
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Clinical Biochemistry
Cite this
Alterations of cerebral blood flow and antiphospholipid antibodies in patients with systemic lupus erythematosus. / Postiglione, A.; De Chiara, S.; Soricelli, A.; Oriente, A.; Ruocco, A.; Spadaro, G.; Montefusco, S.; Marone, G.; Genovese, A.
In: International Journal of Clinical & Laboratory Research, Vol. 28, No. 1, 04.1998, p. 34-38.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alterations of cerebral blood flow and antiphospholipid antibodies in patients with systemic lupus erythematosus
AU - Postiglione, A.
AU - De Chiara, S.
AU - Soricelli, A.
AU - Oriente, A.
AU - Ruocco, A.
AU - Spadaro, G.
AU - Montefusco, S.
AU - Marone, G.
AU - Genovese, A.
PY - 1998/4
Y1 - 1998/4
N2 - Twenty-two patients with systemic lupus erythematosus and 13 healthy controls were included in a cerebral blood flow study and underwent brain-dedicated sin gle-photon emission computed tomography using (99m)technetium-d, 1-hexamethylpropylene amine oxime together with a brain computed tomography scan. Plasma levels of antiphospholipid anitibodies (lupus anticoagulant and anticardiolipin IgM and IgG antibodies) were- also determined. Brain computed tomography showed: signs of focal cerebral ischemia in 4 patients (18%), whereas cerebral blood flow by single-photon emission computed tomography was abnormal in 13 of 22 patients (59%), who showed bilateral or monolateral hypoperfusion in the temporo-parietal regions. Patients with abnormal cerebral blood flow had a longer duration of disease than those with normal blood flow (8.9 ± 1.9 years vs. 5.3 ± 1.5 years, P
AB - Twenty-two patients with systemic lupus erythematosus and 13 healthy controls were included in a cerebral blood flow study and underwent brain-dedicated sin gle-photon emission computed tomography using (99m)technetium-d, 1-hexamethylpropylene amine oxime together with a brain computed tomography scan. Plasma levels of antiphospholipid anitibodies (lupus anticoagulant and anticardiolipin IgM and IgG antibodies) were- also determined. Brain computed tomography showed: signs of focal cerebral ischemia in 4 patients (18%), whereas cerebral blood flow by single-photon emission computed tomography was abnormal in 13 of 22 patients (59%), who showed bilateral or monolateral hypoperfusion in the temporo-parietal regions. Patients with abnormal cerebral blood flow had a longer duration of disease than those with normal blood flow (8.9 ± 1.9 years vs. 5.3 ± 1.5 years, P
KW - Antiphospholipid antibodies
KW - Cerebral blood flow
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=0031960501&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031960501&partnerID=8YFLogxK
U2 - 10.1007/s005990050015
DO - 10.1007/s005990050015
M3 - Article
VL - 28
SP - 34
EP - 38
JO - Ricerca in Clinica e in Laboratorio
JF - Ricerca in Clinica e in Laboratorio
SN - 0940-5437
IS - 1
ER -