Alterations of circulating endogenous secretory RAGE and S100A9 levels indicating dysfunction of the AGE-RAGE axis in autism

Marianna Boso, Enzo Emanuele, Piercarlo Minoretti, Mariarosa Arra, Pierluigi Politi, Stefania Ucelli di Nemi, Francesco Barale

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

An excess accumulation of advanced glycation end products (AGEs) has been reported in autism brains. Through their interaction with their putative receptor RAGE, AGEs can promote neuroinflammation, oxidative stress and neuronal degeneration. To shed more light on the possible alterations of the AGEs-RAGE axis in autism, hereto we measured plasma levels of endogenous secretory RAGE (esRAGE) and its proinflammatory ligand S100A9 in 18 young adults with autistic spectrum disorder (ASD) and 18 age- and gender-matched healthy comparison subjects. The Childhood Autism Rating Scale (CARS) was used to assess the severity of autistic symptoms. Significantly reduced levels of esRAGE (P = 0.0023) and elevated concentrations of S100A9 (P = 0.0012) were found in ASD patients as compared to controls. In autistic patients, there was a statistically significant positive correlation between CARS scores and S100A9 levels (r = 0.49, P = 0.035), but no significant correlation was seen between esRAGE and S100A9 values (r = -0.23, P = 0.34). Our results of a significantly reduced peripheral level of esRAGE coupled with elevated S100A9 point to a subtle but definite dysfunction of the AGEs/RAGE axis in autism that could play a role in the pathophysiology of this disorder.

Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalNeuroscience Letters
Volume410
Issue number3
DOIs
Publication statusPublished - Dec 27 2006

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Autistic Disorder
Advanced Glycosylation End Products
human esRAGE protein
Young Adult
Healthy Volunteers
Oxidative Stress
Ligands
Brain

Keywords

  • Advanced glycation end products
  • Autistic spectrum disorders
  • Calgranulins
  • ELISA
  • Oxidative stress

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alterations of circulating endogenous secretory RAGE and S100A9 levels indicating dysfunction of the AGE-RAGE axis in autism. / Boso, Marianna; Emanuele, Enzo; Minoretti, Piercarlo; Arra, Mariarosa; Politi, Pierluigi; Ucelli di Nemi, Stefania; Barale, Francesco.

In: Neuroscience Letters, Vol. 410, No. 3, 27.12.2006, p. 169-173.

Research output: Contribution to journalArticle

Boso, Marianna ; Emanuele, Enzo ; Minoretti, Piercarlo ; Arra, Mariarosa ; Politi, Pierluigi ; Ucelli di Nemi, Stefania ; Barale, Francesco. / Alterations of circulating endogenous secretory RAGE and S100A9 levels indicating dysfunction of the AGE-RAGE axis in autism. In: Neuroscience Letters. 2006 ; Vol. 410, No. 3. pp. 169-173.
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