Alterations of coagulation and fibrinolysis in patients with angioedema due to C1-inhibitor deficiency

M. Van Geffen, M. Cugno, P. Lap, A. Loof, M. Cicardi, W. Van Heerde

Research output: Contribution to journalArticle

Abstract

Patients with functional deficiency of C1-inhibitor (C1-INH) suffer from recurrent acute attacks (AA) of localized oedema associated with activation of the contact system, complement and fibrinolysis. To unravel further the role of coagulation and fibrinolysis in the pathophysiology of C1-INH deficiency, we performed simultaneous thrombin and plasmin generation measurements in plasma from patients with hereditary angioedema (HAE) due to C1-INH deficiency during AA (n=23), in remission (R) (n=20) and in controls (n=20). During AA thrombin generation after in-vitro activation of plasma was higher than in controls, as demonstrated by shorter thrombin peak-time (P

Original languageEnglish
Pages (from-to)472-478
Number of pages7
JournalClinical and Experimental Immunology
Volume167
Issue number3
DOIs
Publication statusPublished - Mar 2012

Keywords

  • Activation
  • Proteases
  • Thrombosis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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