Alterations of exocrine pancreas in end-stage renal disease do they reflect a clinically relevant uremic pancreopathy?

M. Ventrucci, C. Campieri, M. Di Stefano, G. M. Ubalducci, S. Li Bassi, A. Di Grazia, A. Giudicissi, D. Festi

Research output: Contribution to journalArticlepeer-review

Abstract

Serum pancreatic enzyme behavior, exocrine function, and morphology of the pancreas were studied in 28 patients with end-stage renal disease undergoing regular hemodialysis, in order to better delineate and assess the clinical relevance of the pancreatic alterations that occur in these patients. Twenty-eight healthy subjects served as controls. Initial studies included serum amylase, isoamylase, and lipase assays; fecal chymotrypsin measurement; and abdominal ultrasonography. The amylase, lipase, and chymotrypsin determinations, as well as ultrasound examination, were repeated four years later. None of the patients had clinical evidence of pancreatic disease at entry into the study, but one had had previous attacks of pancreatitis and another developed mild acute pancreatitis one month after entry. Initial mean serum enzyme levels were significantly higher in patients than in controls (amylase, pancreatic isoamylase, and lipase, P

Original languageEnglish
Pages (from-to)2576-2581
Number of pages6
JournalDigestive Diseases and Sciences
Volume40
Issue number12
DOIs
Publication statusPublished - Dec 1995

Keywords

  • exocrine pancreatic function
  • hemodialysis
  • pancreatitis
  • renal failure
  • serum pancreatic enzymes
  • ultrasonography

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Alterations of exocrine pancreas in end-stage renal disease do they reflect a clinically relevant uremic pancreopathy?'. Together they form a unique fingerprint.

Cite this