Alterations of haemorheological parameters in patients with Peripheral Arterial Disease

I. Ricci, F. Sofi, A. Alessandrello Liotta, S. Fedi, C. Macchi, G. Pratesi, R. Pulli, C. Pratesi, R. Abbate, L. Mannini

Research output: Contribution to journalArticlepeer-review

Abstract

Peripheral arterial disease (PAD), is a common manifestation of systemic atherosclerosis. Advances on the development of such vascular disease have described with a number of novel risk factors. Hyperviscosity, due to alterations of blood cells and plasma components, may play a role on the pathogenesis of the disease. Aim of this study was to evaluate the possible association between hemorheological variables and PAD. The hemorheological variables [whole blood viscosity (WBV), erythrocyte deformability index (DI), plasma viscosity (PLV)] were analyzed in 90 patients and in 180 healthy subjects. WBV and PLV were measured by a Rotational Viscosimeter and DI by a filtrometer. DI and PLV were significantly different in patients as compared to controls. To investigate the possible association between these parameters and the disease we divided the study population into tertiles. At the univariate analysis, we found a significant association between the highest tertiles of PLV, of DI and the disease. A model adjusted for traditional risk factors showed an association between highest tertiles of PLV and PAD. After adjustment for confounding parameters highest tertiles of PLV remained to be significantly associated with the disease. Our data indicate that an alteration of plasma viscosity may modulate the predisposition to PAD.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalClinical Hemorheology and Microcirculation
Volume55
Issue number2
DOIs
Publication statusPublished - 2013

Keywords

  • Erythrocyte deformability index
  • Hemorheological variables
  • Peripheral arterial disease
  • Plasma viscosity
  • Whole blood viscosity

ASJC Scopus subject areas

  • Hematology
  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

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