Alterations of haemostatic and fibrinolytic markers in adult patients with growth hormone deficiency and with acromegaly

A. Sartorio, M. Cattaneo, P. Bucciarelli, B. Bottasso, S. Porretti, P. Epaminonda, G. Faglia, M. Arosio

Research output: Contribution to journalArticle

Abstract

Alterations of coagulation and fibrinolytic systems might contribute to the increased cardiovascular and cerebrovascular mortality observed in patients with both chronic growth hormone (GH) excess (acromegaly) and deficiency (GHD). However, contrasting results have been so far reported. To assess the importance of GH in modulating haemostatic system, several haemostatic variables in patients with GHD and acromegaly were measured. Twenty-four adult patients with GHD (8 childhood- and 16 adult-onset; age: 41±12 years, insulin like growth factor-I, IGF-I: 6.7±4 nmol/L), 10 non-diabetic acromegalic patients (age: 39±15 years; IGF-I: 109±37 nmol/L) and 64 healthy volunteers age- and sex-matched with cases were studied. The plasma levels of tissue-type plasminogen activator antigen (t-PA), prothrombin fragment 1+2 (F1+2) and thrombin-antithrombin complex (TAT) were measured by ELISA. Plasminogen activator inhibitor type 1 (PAI-1) was measured by an immunoactivity assay and fibrinogen by von Clauss method. GH levels were measured by IFMA and IGF-I by RIA. GHD patients had higher PAI-1 (12.7±16.7 vs 4.8±5.3 U/ml, p

Original languageEnglish
Pages (from-to)486-492
Number of pages7
JournalExperimental and Clinical Endocrinology and Diabetes
Volume108
Issue number7
DOIs
Publication statusPublished - 2000

Keywords

  • Acromegaly
  • Fibrinogen
  • Growth hormone deficiency
  • Plasminogen activator inhibitor 1 and coagulation variables

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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