Alterations of in vitro lymphocyte proliferation and immunoglobulin production in primary Kaposi's sarcoma

L. Brambilla; R. Chianese; P. Bernasconi; F. Parini; M. G. Gagliano; G. F. Fiorini

Alterations of in vitro lymphocyte proliferation and immunoglobulin production in primary Kaposi's sarcoma

L. Brambilla, R. Chianese, P. Bernasconi, F. Parini, M. G. Gagliano, G. F. Fiorini

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Mitogen induced lymphocyte proliferation and immunoglobulin production in vitro have been evaluated in 15 patients with primary Kaposi's sarcoma and in 10 control subjects. Determinations of serum immunoglobulins, complement fractions, immune complexes and β2 microglobulin have also been carried out. While serological tests showed only an increased level of immune complexes, the data on lymphocyte function revealed several major abnormalities. These abnromalities are comparable to those seen in Kaposi's sarcoma associated with the Acquired Immunodeficiency Syndrome, though the quantitative alterations in lymphocyte subsets typical of the latter, are absent in the primary form.

Original language	English
Title of host publication	Annali Italiani di Dermatologia Clinica e Sperimentale
Pages	5-12
Number of pages	8
Volume	42
Edition	1
Publication status	Published - 1988

ASJC Scopus subject areas

Dermatology

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AU - Brambilla, L.

AU - Chianese, R.

AU - Bernasconi, P.

AU - Parini, F.

AU - Gagliano, M. G.

AU - Fiorini, G. F.

PY - 1988

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AB - Mitogen induced lymphocyte proliferation and immunoglobulin production in vitro have been evaluated in 15 patients with primary Kaposi's sarcoma and in 10 control subjects. Determinations of serum immunoglobulins, complement fractions, immune complexes and β2 microglobulin have also been carried out. While serological tests showed only an increased level of immune complexes, the data on lymphocyte function revealed several major abnormalities. These abnromalities are comparable to those seen in Kaposi's sarcoma associated with the Acquired Immunodeficiency Syndrome, though the quantitative alterations in lymphocyte subsets typical of the latter, are absent in the primary form.

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