Alterations of left ventricular deformation and cardiac sympathetic derangement in patients with systolic heart failure: a 3D speckle tracking echocardiography and cardiac 123I-MIBG study

Dario Leosco, Valentina Parisi, Teresa Pellegrino, Gennaro Pagano, Grazia Daniela Femminella, Agnese Bevilacqua, Stefania Paolillo, Roberto Formisano, Gaetana Ferro, Claudio de Lucia, Maria Prastaro, Pasquale Perrone Filardi, Alberto Cuocolo, Giuseppe Rengo, Nicola Ferrara

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Myocardial contractile function is under the control of cardiac sympathetic activity. Three-dimensional speckle tracking echocardiography (3D-STE) and cardiac imaging with 123I-metaiodobenzylguanidine (123I-MIBG) are two sophisticated techniques for the assessment of left ventricular (LV) deformation and sympathetic innervation, respectively, which offer important prognostic information in patients with heart failure (HF). The purpose of this investigation was to explore, in patients with systolic HF, the relationship between LV deformation assessed by 3D-STE and cardiac sympathetic derangement evaluated by 123I-MIBG imaging. Methods: We prospectively studied 75 patients with systolic HF. All patients underwent a 3D-STE study (longitudinal, circumferential, area and radial) and 123I-MIBG planar and SPECT cardiac imaging. Results: 3D-STE longitudinal, circumferential and area strain values were correlated with 123I-MIBG late heart to mediastinum (H/M) ratio and late SPECT total defect score. After stratification of the patients according to ischaemic or nonischaemic HF aetiology, we observed a good correlation of all 3D-STE measurements with late H/M ratio and SPECT data in the ischaemic group, but in patients with HF of nonischaemic aetiology, no correlation was found between LV deformation and cardiac sympathetic activity. At the regional level, the strongest correlation between LV deformation and adrenergic innervation was found for the left anterior descending coronary artery distribution territory for all four 3D-STE values. In multivariate linear regression analyses, including age, gender, LV ejection fraction, NYHA class, body mass index, heart rate and HF aetiology, only 3D-STE area and radial strain values significantly predicted cardiac sympathetic derangement on 123I-MIBG late SPECT. Conclusion: This study indicated that 3D-STE measurements are correlated with 123I-MIBG planar and SPECT data. Furthermore, 3D-STE area and radial strain values, but not LVEF, predict cardiac sympathetic derangement in human postischaemic HF.

Original languageEnglish
Pages (from-to)1601-1611
Number of pages11
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume42
Issue number10
DOIs
Publication statusPublished - May 7 2015

Keywords

  • <sup>123</sup>I-MIBG cardiac imaging
  • <sup>123</sup>I-MIBG planar imaging
  • <sup>123</sup>I-MIBG SPECT
  • 3D-Speckle Tracking Echocardiography
  • Cardiac sympathetic derangement
  • Left ventricular deformation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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