Alterations of Neuromuscular Function after the World's Most Challenging Mountain Ultra-Marathon

Jonas Saugy, Nicolas Place, Guillaume Y. Millet, Francis Degache, Federico Schena, Grégoire P. Millet

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

We investigated the physiological consequences of the most challenging mountain ultra-marathon (MUM) in the world: a 330-km trail run with 24000 m of positive and negative elevation change. Neuromuscular fatigue (NMF) was assessed before (Pre-), during (Mid-) and after (Post-) the MUM in experienced ultra-marathon runners (n = 15; finish time = 122.43 hours ±17.21 hours) and in Pre- and Post- in a control group with a similar level of sleep deprivation (n = 8). Blood markers of muscle inflammation and damage were analyzed at Pre- and Post-. Mean ± SD maximal voluntary contraction force declined significantly at Mid- (-13±17% and -10±16%, P1), lactate dehydrogenase (1145±511 UI·L-1), C-Reactive Protein (13.1±7.5 mg·L-1) and myoglobin (449.3±338.2 μg·L-1) were higher (P

Original languageEnglish
Article numbere65596
JournalPLoS One
Volume8
Issue number6
DOIs
Publication statusPublished - Jun 26 2013

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Sleep Deprivation
Myoglobin
L-Lactate Dehydrogenase
C-Reactive Protein
Fatigue
Muscle
Blood
mountains
Fatigue of materials
Inflammation
Muscles
Control Groups
myoglobin
C-reactive protein
lactate dehydrogenase
inflammation
muscles
blood
Sleep
sleep deprivation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Alterations of Neuromuscular Function after the World's Most Challenging Mountain Ultra-Marathon. / Saugy, Jonas; Place, Nicolas; Millet, Guillaume Y.; Degache, Francis; Schena, Federico; Millet, Grégoire P.

In: PLoS One, Vol. 8, No. 6, e65596, 26.06.2013.

Research output: Contribution to journalArticle

Saugy, Jonas ; Place, Nicolas ; Millet, Guillaume Y. ; Degache, Francis ; Schena, Federico ; Millet, Grégoire P. / Alterations of Neuromuscular Function after the World's Most Challenging Mountain Ultra-Marathon. In: PLoS One. 2013 ; Vol. 8, No. 6.
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