Alterations of Neuromuscular Function after the World's Most Challenging Mountain Ultra-Marathon

Jonas Saugy, Nicolas Place, Guillaume Y. Millet, Francis Degache, Federico Schena, Grégoire P. Millet

Research output: Contribution to journalArticlepeer-review


We investigated the physiological consequences of the most challenging mountain ultra-marathon (MUM) in the world: a 330-km trail run with 24000 m of positive and negative elevation change. Neuromuscular fatigue (NMF) was assessed before (Pre-), during (Mid-) and after (Post-) the MUM in experienced ultra-marathon runners (n = 15; finish time = 122.43 hours ±17.21 hours) and in Pre- and Post- in a control group with a similar level of sleep deprivation (n = 8). Blood markers of muscle inflammation and damage were analyzed at Pre- and Post-. Mean ± SD maximal voluntary contraction force declined significantly at Mid- (-13±17% and -10±16%, P1), lactate dehydrogenase (1145±511 UI·L-1), C-Reactive Protein (13.1±7.5 mg·L-1) and myoglobin (449.3±338.2 μg·L-1) were higher (P

Original languageEnglish
Article numbere65596
JournalPLoS One
Issue number6
Publication statusPublished - Jun 26 2013

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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