Alterations of synaptic turnover rate in aging may trigger senile plaque formation and neurodegeneration

Carlo Bertoni-Freddari, Patrizia Fattoretti, Belinda Giorgetti, Yessica Grossi, Marta Balietti, Tiziana Casoli, Giuseppina Di Stefano, Gemma Perretta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Citations (Scopus)

Abstract

The changes of synaptic ultrastructure were investigated by morphometry in the frontal (FC) and temporal (TC) cortex of adult and aged monkeys, to assess the potential role of age-related synaptic deterioration in neurodegeneration. The average synaptic size (S), the synaptic numeric density (Nv: number of synapses/μm3 of tissue), the synaptic surface density (Sv: overall area of synaptic junctional zones/μm3 of tissue), and the number of synapses/neuron (Syn/Neur) were calculated. In FC, significant differences of Nv and Sv due to age were not revealed, while the S value was significantly increased in the aged animals. In TC, Sv did not change in relation to age, whereas Nv was significantly decreased and S significantly increased in aged monkeys. A percent distribution of S showed that the fraction of enlarged synapses (>0.20 μm2) was higher in TC than in FC, regardless of the age of the animals (21.3% versus 16.9% in adult and 33.9% versus 26.0% in aged monkeys, respectively). In aged animals, Syn/Neur was not significantly decreased in TC and not significantly increased in FC (4.4%). The above morphometric parameters account for the ongoing rearrangements of synaptic ultrastructure, reacting to the environmental stimuli. Our findings provide evidence of an age-related decline of synaptic plasticity in the brain of aged monkeys that is statistically significant in TC. According to current literature data on synaptic structural dynamics, this decay may represent an early and subtle alteration able to trigger the development of senile plaques and neurodegenerative events.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages128-137
Number of pages10
Volume1096
DOIs
Publication statusPublished - Jan 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1096
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Amyloid Plaques
Synapses
Haplorhini
Animals
Aging of materials
Neurons
Tissue
Structural dynamics
Neuronal Plasticity
Plasticity
Deterioration
Brain
Temporal Lobe

Keywords

  • Alzheimer's disease
  • E-PTA staining
  • Macaca fascicularis
  • Senile plaques
  • Synaptic morphometry
  • Synaptic numeric density
  • Synaptic pathology
  • Synaptic perforations
  • Synaptic plasticity
  • Synaptic size

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bertoni-Freddari, C., Fattoretti, P., Giorgetti, B., Grossi, Y., Balietti, M., Casoli, T., ... Perretta, G. (2007). Alterations of synaptic turnover rate in aging may trigger senile plaque formation and neurodegeneration. In Annals of the New York Academy of Sciences (Vol. 1096, pp. 128-137). (Annals of the New York Academy of Sciences; Vol. 1096). https://doi.org/10.1196/annals.1397.078

Alterations of synaptic turnover rate in aging may trigger senile plaque formation and neurodegeneration. / Bertoni-Freddari, Carlo; Fattoretti, Patrizia; Giorgetti, Belinda; Grossi, Yessica; Balietti, Marta; Casoli, Tiziana; Di Stefano, Giuseppina; Perretta, Gemma.

Annals of the New York Academy of Sciences. Vol. 1096 2007. p. 128-137 (Annals of the New York Academy of Sciences; Vol. 1096).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bertoni-Freddari, C, Fattoretti, P, Giorgetti, B, Grossi, Y, Balietti, M, Casoli, T, Di Stefano, G & Perretta, G 2007, Alterations of synaptic turnover rate in aging may trigger senile plaque formation and neurodegeneration. in Annals of the New York Academy of Sciences. vol. 1096, Annals of the New York Academy of Sciences, vol. 1096, pp. 128-137. https://doi.org/10.1196/annals.1397.078
Bertoni-Freddari C, Fattoretti P, Giorgetti B, Grossi Y, Balietti M, Casoli T et al. Alterations of synaptic turnover rate in aging may trigger senile plaque formation and neurodegeneration. In Annals of the New York Academy of Sciences. Vol. 1096. 2007. p. 128-137. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1397.078
Bertoni-Freddari, Carlo ; Fattoretti, Patrizia ; Giorgetti, Belinda ; Grossi, Yessica ; Balietti, Marta ; Casoli, Tiziana ; Di Stefano, Giuseppina ; Perretta, Gemma. / Alterations of synaptic turnover rate in aging may trigger senile plaque formation and neurodegeneration. Annals of the New York Academy of Sciences. Vol. 1096 2007. pp. 128-137 (Annals of the New York Academy of Sciences).
@inproceedings{5d6f876dee684c8a84725e691d0d1ca3,
title = "Alterations of synaptic turnover rate in aging may trigger senile plaque formation and neurodegeneration",
abstract = "The changes of synaptic ultrastructure were investigated by morphometry in the frontal (FC) and temporal (TC) cortex of adult and aged monkeys, to assess the potential role of age-related synaptic deterioration in neurodegeneration. The average synaptic size (S), the synaptic numeric density (Nv: number of synapses/μm3 of tissue), the synaptic surface density (Sv: overall area of synaptic junctional zones/μm3 of tissue), and the number of synapses/neuron (Syn/Neur) were calculated. In FC, significant differences of Nv and Sv due to age were not revealed, while the S value was significantly increased in the aged animals. In TC, Sv did not change in relation to age, whereas Nv was significantly decreased and S significantly increased in aged monkeys. A percent distribution of S showed that the fraction of enlarged synapses (>0.20 μm2) was higher in TC than in FC, regardless of the age of the animals (21.3{\%} versus 16.9{\%} in adult and 33.9{\%} versus 26.0{\%} in aged monkeys, respectively). In aged animals, Syn/Neur was not significantly decreased in TC and not significantly increased in FC (4.4{\%}). The above morphometric parameters account for the ongoing rearrangements of synaptic ultrastructure, reacting to the environmental stimuli. Our findings provide evidence of an age-related decline of synaptic plasticity in the brain of aged monkeys that is statistically significant in TC. According to current literature data on synaptic structural dynamics, this decay may represent an early and subtle alteration able to trigger the development of senile plaques and neurodegenerative events.",
keywords = "Alzheimer's disease, E-PTA staining, Macaca fascicularis, Senile plaques, Synaptic morphometry, Synaptic numeric density, Synaptic pathology, Synaptic perforations, Synaptic plasticity, Synaptic size",
author = "Carlo Bertoni-Freddari and Patrizia Fattoretti and Belinda Giorgetti and Yessica Grossi and Marta Balietti and Tiziana Casoli and {Di Stefano}, Giuseppina and Gemma Perretta",
year = "2007",
month = "1",
doi = "10.1196/annals.1397.078",
language = "English",
isbn = "1573316970",
volume = "1096",
series = "Annals of the New York Academy of Sciences",
pages = "128--137",
booktitle = "Annals of the New York Academy of Sciences",

}

TY - GEN

T1 - Alterations of synaptic turnover rate in aging may trigger senile plaque formation and neurodegeneration

AU - Bertoni-Freddari, Carlo

AU - Fattoretti, Patrizia

AU - Giorgetti, Belinda

AU - Grossi, Yessica

AU - Balietti, Marta

AU - Casoli, Tiziana

AU - Di Stefano, Giuseppina

AU - Perretta, Gemma

PY - 2007/1

Y1 - 2007/1

N2 - The changes of synaptic ultrastructure were investigated by morphometry in the frontal (FC) and temporal (TC) cortex of adult and aged monkeys, to assess the potential role of age-related synaptic deterioration in neurodegeneration. The average synaptic size (S), the synaptic numeric density (Nv: number of synapses/μm3 of tissue), the synaptic surface density (Sv: overall area of synaptic junctional zones/μm3 of tissue), and the number of synapses/neuron (Syn/Neur) were calculated. In FC, significant differences of Nv and Sv due to age were not revealed, while the S value was significantly increased in the aged animals. In TC, Sv did not change in relation to age, whereas Nv was significantly decreased and S significantly increased in aged monkeys. A percent distribution of S showed that the fraction of enlarged synapses (>0.20 μm2) was higher in TC than in FC, regardless of the age of the animals (21.3% versus 16.9% in adult and 33.9% versus 26.0% in aged monkeys, respectively). In aged animals, Syn/Neur was not significantly decreased in TC and not significantly increased in FC (4.4%). The above morphometric parameters account for the ongoing rearrangements of synaptic ultrastructure, reacting to the environmental stimuli. Our findings provide evidence of an age-related decline of synaptic plasticity in the brain of aged monkeys that is statistically significant in TC. According to current literature data on synaptic structural dynamics, this decay may represent an early and subtle alteration able to trigger the development of senile plaques and neurodegenerative events.

AB - The changes of synaptic ultrastructure were investigated by morphometry in the frontal (FC) and temporal (TC) cortex of adult and aged monkeys, to assess the potential role of age-related synaptic deterioration in neurodegeneration. The average synaptic size (S), the synaptic numeric density (Nv: number of synapses/μm3 of tissue), the synaptic surface density (Sv: overall area of synaptic junctional zones/μm3 of tissue), and the number of synapses/neuron (Syn/Neur) were calculated. In FC, significant differences of Nv and Sv due to age were not revealed, while the S value was significantly increased in the aged animals. In TC, Sv did not change in relation to age, whereas Nv was significantly decreased and S significantly increased in aged monkeys. A percent distribution of S showed that the fraction of enlarged synapses (>0.20 μm2) was higher in TC than in FC, regardless of the age of the animals (21.3% versus 16.9% in adult and 33.9% versus 26.0% in aged monkeys, respectively). In aged animals, Syn/Neur was not significantly decreased in TC and not significantly increased in FC (4.4%). The above morphometric parameters account for the ongoing rearrangements of synaptic ultrastructure, reacting to the environmental stimuli. Our findings provide evidence of an age-related decline of synaptic plasticity in the brain of aged monkeys that is statistically significant in TC. According to current literature data on synaptic structural dynamics, this decay may represent an early and subtle alteration able to trigger the development of senile plaques and neurodegenerative events.

KW - Alzheimer's disease

KW - E-PTA staining

KW - Macaca fascicularis

KW - Senile plaques

KW - Synaptic morphometry

KW - Synaptic numeric density

KW - Synaptic pathology

KW - Synaptic perforations

KW - Synaptic plasticity

KW - Synaptic size

UR - http://www.scopus.com/inward/record.url?scp=34247213423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247213423&partnerID=8YFLogxK

U2 - 10.1196/annals.1397.078

DO - 10.1196/annals.1397.078

M3 - Conference contribution

C2 - 17405924

AN - SCOPUS:34247213423

SN - 1573316970

SN - 9781573316972

VL - 1096

T3 - Annals of the New York Academy of Sciences

SP - 128

EP - 137

BT - Annals of the New York Academy of Sciences

ER -