Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders

Donatella Marazziti; Mario Catena Dell'Osso; Stefano Baroni; Irene Masala; Bernardo Dell'Osso; Giorgio Consoli; Gino Giannaccini; Laura Betti; Antonio Lucacchini

doi:10.1016/j.psychres.2009.03.009

Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders

Donatella Marazziti, Mario Catena Dell'Osso, Stefano Baroni, Irene Masala, Bernardo Dell'Osso, Giorgio Consoli, Gino Giannaccini, Laura Betti, Antonio Lucacchini

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of our study was to investigate and compare the dopamine (DA) transporter (DAT) in resting lymphocytes of 20 psychotic patients and 20 healthy control subjects, by means of both the binding parameters (Bmax and Kd) of ³H-WIN 35,428, and the reuptake parameters (Vmax and Km) of ³H-DA. The results showed that both the Bmax of ³H-WIN 35,428 binding and the Vmax of ³H-DA reuptake of the patients were significantly lower than those of healthy subjects, while the Kd or Km did not show any change. These findings, while indicating a reduced density of the lymphocyte DAT proteins, provide further support of the role of DA in psychoses and suggest that DA alterations may not be limited to brain structures.

Original language	English
Pages (from-to)	54-57
Number of pages	4
Journal	Psychiatry Research
Volume	175
Issue number	1-2
DOIs	https://doi.org/10.1016/j.psychres.2009.03.009
Publication status	Published - Jan 30 2010

Keywords

H-WIN 35,428 binding
Bipolar disorders
Dopamine
Dopamine reuptake
Dopamine transporter
Humans
Resting lymphocytes
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

Access to Document

10.1016/j.psychres.2009.03.009

Fingerprint Dive into the research topics of 'Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders'. Together they form a unique fingerprint.

Cite this

Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders. / Marazziti, Donatella; Catena Dell'Osso, Mario; Baroni, Stefano; Masala, Irene; Dell'Osso, Bernardo; Consoli, Giorgio; Giannaccini, Gino; Betti, Laura; Lucacchini, Antonio.

In: Psychiatry Research, Vol. 175, No. 1-2, 30.01.2010, p. 54-57.

Research output: Contribution to journal › Article › peer-review

@article{32bfa32a13c5436098a6fb92daaccff2,

title = "Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders",

abstract = "The aim of our study was to investigate and compare the dopamine (DA) transporter (DAT) in resting lymphocytes of 20 psychotic patients and 20 healthy control subjects, by means of both the binding parameters (Bmax and Kd) of 3H-WIN 35,428, and the reuptake parameters (Vmax and Km) of 3H-DA. The results showed that both the Bmax of 3H-WIN 35,428 binding and the Vmax of 3H-DA reuptake of the patients were significantly lower than those of healthy subjects, while the Kd or Km did not show any change. These findings, while indicating a reduced density of the lymphocyte DAT proteins, provide further support of the role of DA in psychoses and suggest that DA alterations may not be limited to brain structures.",

keywords = "H-WIN 35,428 binding, Bipolar disorders, Dopamine, Dopamine reuptake, Dopamine transporter, Humans, Resting lymphocytes, Schizophrenia",

author = "Donatella Marazziti and {Catena Dell'Osso}, Mario and Stefano Baroni and Irene Masala and Bernardo Dell'Osso and Giorgio Consoli and Gino Giannaccini and Laura Betti and Antonio Lucacchini",

year = "2010",

month = jan,

day = "30",

doi = "10.1016/j.psychres.2009.03.009",

language = "English",

volume = "175",

pages = "54--57",

journal = "Psychiatry Research",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders

AU - Marazziti, Donatella

AU - Catena Dell'Osso, Mario

AU - Baroni, Stefano

AU - Masala, Irene

AU - Dell'Osso, Bernardo

AU - Consoli, Giorgio

AU - Giannaccini, Gino

AU - Betti, Laura

AU - Lucacchini, Antonio

PY - 2010/1/30

Y1 - 2010/1/30

N2 - The aim of our study was to investigate and compare the dopamine (DA) transporter (DAT) in resting lymphocytes of 20 psychotic patients and 20 healthy control subjects, by means of both the binding parameters (Bmax and Kd) of 3H-WIN 35,428, and the reuptake parameters (Vmax and Km) of 3H-DA. The results showed that both the Bmax of 3H-WIN 35,428 binding and the Vmax of 3H-DA reuptake of the patients were significantly lower than those of healthy subjects, while the Kd or Km did not show any change. These findings, while indicating a reduced density of the lymphocyte DAT proteins, provide further support of the role of DA in psychoses and suggest that DA alterations may not be limited to brain structures.

AB - The aim of our study was to investigate and compare the dopamine (DA) transporter (DAT) in resting lymphocytes of 20 psychotic patients and 20 healthy control subjects, by means of both the binding parameters (Bmax and Kd) of 3H-WIN 35,428, and the reuptake parameters (Vmax and Km) of 3H-DA. The results showed that both the Bmax of 3H-WIN 35,428 binding and the Vmax of 3H-DA reuptake of the patients were significantly lower than those of healthy subjects, while the Kd or Km did not show any change. These findings, while indicating a reduced density of the lymphocyte DAT proteins, provide further support of the role of DA in psychoses and suggest that DA alterations may not be limited to brain structures.

KW - H-WIN 35,428 binding

KW - Bipolar disorders

KW - Dopamine

KW - Dopamine reuptake

KW - Dopamine transporter

KW - Humans

KW - Resting lymphocytes

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=72149114082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=72149114082&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2009.03.009

DO - 10.1016/j.psychres.2009.03.009

M3 - Article

C2 - 19910055

AN - SCOPUS:72149114082

VL - 175

SP - 54

EP - 57

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 1-2

ER -