Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders

Donatella Marazziti, Mario Catena Dell'Osso, Stefano Baroni, Irene Masala, Bernardo Dell'Osso, Giorgio Consoli, Gino Giannaccini, Laura Betti, Antonio Lucacchini

Research output: Contribution to journalArticle

Abstract

The aim of our study was to investigate and compare the dopamine (DA) transporter (DAT) in resting lymphocytes of 20 psychotic patients and 20 healthy control subjects, by means of both the binding parameters (Bmax and Kd) of 3H-WIN 35,428, and the reuptake parameters (Vmax and Km) of 3H-DA. The results showed that both the Bmax of 3H-WIN 35,428 binding and the Vmax of 3H-DA reuptake of the patients were significantly lower than those of healthy subjects, while the Kd or Km did not show any change. These findings, while indicating a reduced density of the lymphocyte DAT proteins, provide further support of the role of DA in psychoses and suggest that DA alterations may not be limited to brain structures.

Original languageEnglish
Pages (from-to)54-57
Number of pages4
JournalPsychiatry Research
Volume175
Issue number1-2
DOIs
Publication statusPublished - Jan 30 2010

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Dopamine Plasma Membrane Transport Proteins
Psychotic Disorders
Dopamine
Lymphocytes
Healthy Volunteers
Brain
Proteins

Keywords

  • H-WIN 35,428 binding
  • Bipolar disorders
  • Dopamine
  • Dopamine reuptake
  • Dopamine transporter
  • Humans
  • Resting lymphocytes
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders. / Marazziti, Donatella; Catena Dell'Osso, Mario; Baroni, Stefano; Masala, Irene; Dell'Osso, Bernardo; Consoli, Giorgio; Giannaccini, Gino; Betti, Laura; Lucacchini, Antonio.

In: Psychiatry Research, Vol. 175, No. 1-2, 30.01.2010, p. 54-57.

Research output: Contribution to journalArticle

Marazziti, D, Catena Dell'Osso, M, Baroni, S, Masala, I, Dell'Osso, B, Consoli, G, Giannaccini, G, Betti, L & Lucacchini, A 2010, 'Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders', Psychiatry Research, vol. 175, no. 1-2, pp. 54-57. https://doi.org/10.1016/j.psychres.2009.03.009
Marazziti, Donatella ; Catena Dell'Osso, Mario ; Baroni, Stefano ; Masala, Irene ; Dell'Osso, Bernardo ; Consoli, Giorgio ; Giannaccini, Gino ; Betti, Laura ; Lucacchini, Antonio. / Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders. In: Psychiatry Research. 2010 ; Vol. 175, No. 1-2. pp. 54-57.
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