Abstract
The aim of our study was to investigate and compare the dopamine (DA) transporter (DAT) in resting lymphocytes of 20 psychotic patients and 20 healthy control subjects, by means of both the binding parameters (Bmax and Kd) of 3H-WIN 35,428, and the reuptake parameters (Vmax and Km) of 3H-DA. The results showed that both the Bmax of 3H-WIN 35,428 binding and the Vmax of 3H-DA reuptake of the patients were significantly lower than those of healthy subjects, while the Kd or Km did not show any change. These findings, while indicating a reduced density of the lymphocyte DAT proteins, provide further support of the role of DA in psychoses and suggest that DA alterations may not be limited to brain structures.
| Original language | English |
|---|---|
| Pages (from-to) | 54-57 |
| Number of pages | 4 |
| Journal | Psychiatry Research |
| Volume | 175 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Jan 30 2010 |
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Keywords
- H-WIN 35,428 binding
- Bipolar disorders
- Dopamine
- Dopamine reuptake
- Dopamine transporter
- Humans
- Resting lymphocytes
- Schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Cite this
Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders. / Marazziti, Donatella; Catena Dell'Osso, Mario; Baroni, Stefano; Masala, Irene; Dell'Osso, Bernardo; Consoli, Giorgio; Giannaccini, Gino; Betti, Laura; Lucacchini, Antonio.
In: Psychiatry Research, Vol. 175, No. 1-2, 30.01.2010, p. 54-57.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders
AU - Marazziti, Donatella
AU - Catena Dell'Osso, Mario
AU - Baroni, Stefano
AU - Masala, Irene
AU - Dell'Osso, Bernardo
AU - Consoli, Giorgio
AU - Giannaccini, Gino
AU - Betti, Laura
AU - Lucacchini, Antonio
PY - 2010/1/30
Y1 - 2010/1/30
N2 - The aim of our study was to investigate and compare the dopamine (DA) transporter (DAT) in resting lymphocytes of 20 psychotic patients and 20 healthy control subjects, by means of both the binding parameters (Bmax and Kd) of 3H-WIN 35,428, and the reuptake parameters (Vmax and Km) of 3H-DA. The results showed that both the Bmax of 3H-WIN 35,428 binding and the Vmax of 3H-DA reuptake of the patients were significantly lower than those of healthy subjects, while the Kd or Km did not show any change. These findings, while indicating a reduced density of the lymphocyte DAT proteins, provide further support of the role of DA in psychoses and suggest that DA alterations may not be limited to brain structures.
AB - The aim of our study was to investigate and compare the dopamine (DA) transporter (DAT) in resting lymphocytes of 20 psychotic patients and 20 healthy control subjects, by means of both the binding parameters (Bmax and Kd) of 3H-WIN 35,428, and the reuptake parameters (Vmax and Km) of 3H-DA. The results showed that both the Bmax of 3H-WIN 35,428 binding and the Vmax of 3H-DA reuptake of the patients were significantly lower than those of healthy subjects, while the Kd or Km did not show any change. These findings, while indicating a reduced density of the lymphocyte DAT proteins, provide further support of the role of DA in psychoses and suggest that DA alterations may not be limited to brain structures.
KW - H-WIN 35,428 binding
KW - Bipolar disorders
KW - Dopamine
KW - Dopamine reuptake
KW - Dopamine transporter
KW - Humans
KW - Resting lymphocytes
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=72149114082&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=72149114082&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2009.03.009
DO - 10.1016/j.psychres.2009.03.009
M3 - Article
C2 - 19910055
AN - SCOPUS:72149114082
VL - 175
SP - 54
EP - 57
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 1-2
ER -