Altered β-adrenergic response in mice lacking myotonic dystrophy protein kinase

Esther Llagostera; María Jesúsá Álvarez López; Cecilia Scimia; Daniele Catalucci; Marcelina Párrizas; Pilar Ruiz-Lozano; Perla Kaliman

doi:10.1002/mus.22256

Altered β-adrenergic response in mice lacking myotonic dystrophy protein kinase

Esther Llagostera, María Jesúsá Álvarez López, Cecilia Scimia, Daniele Catalucci, Marcelina Párrizas, Pilar Ruiz-Lozano, Perla Kaliman

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

The protein kinase product of the gene mutated in myotonic dystrophy 1 (DMPK) is reported to play a role in cardiac pathophysiology. To gain insight into the molecular mechanisms modulated by DMPK, we characterize the impact of DMPK ablation in the context of cardiac β-adrenergic function. Our data demonstrate that DMPK knockout mice present altered β-agonist-induced responses and suggest that this is due, at least in part, to a reduced density of β ₁-adrenergic receptors in cardiac plasma membranes.

Original language	English
Pages (from-to)	128-130
Number of pages	3
Journal	Muscle and Nerve
Volume	45
Issue number	1
DOIs	https://doi.org/10.1002/mus.22256
Publication status	Published - Jan 2012

Keywords

β-adrenergic
DMPK
Heart
Isoproterenol
Myotonic dystrophy
Receptor trafficking

ASJC Scopus subject areas

Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)
Physiology

Access to Document

10.1002/mus.22256

Cite this

@article{6defac55d59048e180a43d9e181b51cb,

title = "Altered β-adrenergic response in mice lacking myotonic dystrophy protein kinase",

abstract = "The protein kinase product of the gene mutated in myotonic dystrophy 1 (DMPK) is reported to play a role in cardiac pathophysiology. To gain insight into the molecular mechanisms modulated by DMPK, we characterize the impact of DMPK ablation in the context of cardiac β-adrenergic function. Our data demonstrate that DMPK knockout mice present altered β-agonist-induced responses and suggest that this is due, at least in part, to a reduced density of β 1-adrenergic receptors in cardiac plasma membranes.",

keywords = "β-adrenergic, DMPK, Heart, Isoproterenol, Myotonic dystrophy, Receptor trafficking",

author = "Esther Llagostera and L{\'o}pez, {Mar{\'i}a Jes{\'u}s{\'a} {\'A}lvarez} and Cecilia Scimia and Daniele Catalucci and Marcelina P{\'a}rrizas and Pilar Ruiz-Lozano and Perla Kaliman",

year = "2012",

month = jan,

doi = "10.1002/mus.22256",

language = "English",

volume = "45",

pages = "128--130",

journal = "Muscle and Nerve",

issn = "0148-639X",

publisher = "John Wiley and Sons Inc.",

number = "1",

}

TY - JOUR

T1 - Altered β-adrenergic response in mice lacking myotonic dystrophy protein kinase

AU - Llagostera, Esther

AU - López, María Jesúsá Álvarez

AU - Scimia, Cecilia

AU - Catalucci, Daniele

AU - Párrizas, Marcelina

AU - Ruiz-Lozano, Pilar

AU - Kaliman, Perla

PY - 2012/1

Y1 - 2012/1

N2 - The protein kinase product of the gene mutated in myotonic dystrophy 1 (DMPK) is reported to play a role in cardiac pathophysiology. To gain insight into the molecular mechanisms modulated by DMPK, we characterize the impact of DMPK ablation in the context of cardiac β-adrenergic function. Our data demonstrate that DMPK knockout mice present altered β-agonist-induced responses and suggest that this is due, at least in part, to a reduced density of β 1-adrenergic receptors in cardiac plasma membranes.

AB - The protein kinase product of the gene mutated in myotonic dystrophy 1 (DMPK) is reported to play a role in cardiac pathophysiology. To gain insight into the molecular mechanisms modulated by DMPK, we characterize the impact of DMPK ablation in the context of cardiac β-adrenergic function. Our data demonstrate that DMPK knockout mice present altered β-agonist-induced responses and suggest that this is due, at least in part, to a reduced density of β 1-adrenergic receptors in cardiac plasma membranes.

KW - β-adrenergic

KW - DMPK

KW - Heart

KW - Isoproterenol

KW - Myotonic dystrophy

KW - Receptor trafficking

UR - http://www.scopus.com/inward/record.url?scp=84555188724&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84555188724&partnerID=8YFLogxK

U2 - 10.1002/mus.22256

DO - 10.1002/mus.22256

M3 - Article

C2 - 22190319

AN - SCOPUS:84555188724

VL - 45

SP - 128

EP - 130

JO - Muscle and Nerve

JF - Muscle and Nerve

SN - 0148-639X

IS - 1

ER -

Altered β-adrenergic response in mice lacking myotonic dystrophy protein kinase

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this