Altered 1-14C arachidonic acid metabolism in arterial wall from patients with renal cell carcinoma

G. G. Neri Serneri, R. Abbate, G. F. Gensini

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The metabolism of 1-14C arachidonic acid (AA) by arterial wall in patients with renal cell carcinoma and in control patients undergoing nephrectomy was investigated by a high pressure liquid chromatography (HPLC) system. No differences in 1-14C AA uptake and in the total amount of metabolites were found between the two groups, whereas the amounts of cyclooxygenase and lipoxygenase pathway (COP and LOP) metabolites produced by patients with renal cell carcinoma were significantly lower and, respectively, higher than those produced by the control group. The COP/LOP ratio was 7.2 ± 5.5 in the control group in comparison to 1.9 ± 0.5 in renal cell carcinoma patients. The decrease in COP metabolites was due to a markedly reduced synthesis of prostacyclin (PGI2), with no changes in thromboxane B2 (TxB2), prostaglandin F(2α) (PGF(2α)) and prostaglandin E2 (PGE2) production. The changes in PGI2 and 12-hydroxy-eicosatetraenoic acid (12-HETE) (metabolite of LOP) vascular production were not related to tumor dimension. The decrease in PGI2 synthesis may represent a factor favoring metastasis and thrombosis in neoplastic patients.

Original languageEnglish
Pages (from-to)1071-1074
Number of pages4
JournalJournal of Urology
Volume135
Issue number5
Publication statusPublished - 1986

Fingerprint

Renal Cell Carcinoma
Arachidonic Acid
Epoprostenol
Arachidonic Acids
Thromboxane B2
Control Groups
Hydroxy Acids
Lipoxygenase
Prostaglandins F
Prostaglandin-Endoperoxide Synthases
Nephrectomy
Dinoprostone
Blood Vessels
Thrombosis
High Pressure Liquid Chromatography
Neoplasm Metastasis
Neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Neri Serneri, G. G., Abbate, R., & Gensini, G. F. (1986). Altered 1-14C arachidonic acid metabolism in arterial wall from patients with renal cell carcinoma. Journal of Urology, 135(5), 1071-1074.

Altered 1-14C arachidonic acid metabolism in arterial wall from patients with renal cell carcinoma. / Neri Serneri, G. G.; Abbate, R.; Gensini, G. F.

In: Journal of Urology, Vol. 135, No. 5, 1986, p. 1071-1074.

Research output: Contribution to journalArticle

Neri Serneri, GG, Abbate, R & Gensini, GF 1986, 'Altered 1-14C arachidonic acid metabolism in arterial wall from patients with renal cell carcinoma', Journal of Urology, vol. 135, no. 5, pp. 1071-1074.
Neri Serneri, G. G. ; Abbate, R. ; Gensini, G. F. / Altered 1-14C arachidonic acid metabolism in arterial wall from patients with renal cell carcinoma. In: Journal of Urology. 1986 ; Vol. 135, No. 5. pp. 1071-1074.
@article{374276f7ff3d41fc87f5b01f0f2ec79e,
title = "Altered 1-14C arachidonic acid metabolism in arterial wall from patients with renal cell carcinoma",
abstract = "The metabolism of 1-14C arachidonic acid (AA) by arterial wall in patients with renal cell carcinoma and in control patients undergoing nephrectomy was investigated by a high pressure liquid chromatography (HPLC) system. No differences in 1-14C AA uptake and in the total amount of metabolites were found between the two groups, whereas the amounts of cyclooxygenase and lipoxygenase pathway (COP and LOP) metabolites produced by patients with renal cell carcinoma were significantly lower and, respectively, higher than those produced by the control group. The COP/LOP ratio was 7.2 ± 5.5 in the control group in comparison to 1.9 ± 0.5 in renal cell carcinoma patients. The decrease in COP metabolites was due to a markedly reduced synthesis of prostacyclin (PGI2), with no changes in thromboxane B2 (TxB2), prostaglandin F(2α) (PGF(2α)) and prostaglandin E2 (PGE2) production. The changes in PGI2 and 12-hydroxy-eicosatetraenoic acid (12-HETE) (metabolite of LOP) vascular production were not related to tumor dimension. The decrease in PGI2 synthesis may represent a factor favoring metastasis and thrombosis in neoplastic patients.",
author = "{Neri Serneri}, {G. G.} and R. Abbate and Gensini, {G. F.}",
year = "1986",
language = "English",
volume = "135",
pages = "1071--1074",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Altered 1-14C arachidonic acid metabolism in arterial wall from patients with renal cell carcinoma

AU - Neri Serneri, G. G.

AU - Abbate, R.

AU - Gensini, G. F.

PY - 1986

Y1 - 1986

N2 - The metabolism of 1-14C arachidonic acid (AA) by arterial wall in patients with renal cell carcinoma and in control patients undergoing nephrectomy was investigated by a high pressure liquid chromatography (HPLC) system. No differences in 1-14C AA uptake and in the total amount of metabolites were found between the two groups, whereas the amounts of cyclooxygenase and lipoxygenase pathway (COP and LOP) metabolites produced by patients with renal cell carcinoma were significantly lower and, respectively, higher than those produced by the control group. The COP/LOP ratio was 7.2 ± 5.5 in the control group in comparison to 1.9 ± 0.5 in renal cell carcinoma patients. The decrease in COP metabolites was due to a markedly reduced synthesis of prostacyclin (PGI2), with no changes in thromboxane B2 (TxB2), prostaglandin F(2α) (PGF(2α)) and prostaglandin E2 (PGE2) production. The changes in PGI2 and 12-hydroxy-eicosatetraenoic acid (12-HETE) (metabolite of LOP) vascular production were not related to tumor dimension. The decrease in PGI2 synthesis may represent a factor favoring metastasis and thrombosis in neoplastic patients.

AB - The metabolism of 1-14C arachidonic acid (AA) by arterial wall in patients with renal cell carcinoma and in control patients undergoing nephrectomy was investigated by a high pressure liquid chromatography (HPLC) system. No differences in 1-14C AA uptake and in the total amount of metabolites were found between the two groups, whereas the amounts of cyclooxygenase and lipoxygenase pathway (COP and LOP) metabolites produced by patients with renal cell carcinoma were significantly lower and, respectively, higher than those produced by the control group. The COP/LOP ratio was 7.2 ± 5.5 in the control group in comparison to 1.9 ± 0.5 in renal cell carcinoma patients. The decrease in COP metabolites was due to a markedly reduced synthesis of prostacyclin (PGI2), with no changes in thromboxane B2 (TxB2), prostaglandin F(2α) (PGF(2α)) and prostaglandin E2 (PGE2) production. The changes in PGI2 and 12-hydroxy-eicosatetraenoic acid (12-HETE) (metabolite of LOP) vascular production were not related to tumor dimension. The decrease in PGI2 synthesis may represent a factor favoring metastasis and thrombosis in neoplastic patients.

UR - http://www.scopus.com/inward/record.url?scp=0022558898&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022558898&partnerID=8YFLogxK

M3 - Article

VL - 135

SP - 1071

EP - 1074

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 5

ER -