Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection

Kehmia Titanji, Stefano Sammicheli, Angelo De Milito, Paola Mantegani, Claudio Fortis, Louise Berg, Klas Kärre, Giovanna Travi, Chiara Tassandin, Lucia Lopalco, Bence Rethi, Giuseppe Tambussi, Francesca Chiodi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Human natural killer (NK) (CD3- CD56+) cells can be divided into two functionally distinct subsets, CD3- CD56 dim and CD3- CD56bright. We analysed the distribution of NK cell subsets in primary and chronic human immunodeficiency virus-1 (HIV-1) infection, to determine if HIV infection stage may influence the subset distribution. In primary infection, contrary to chronic infection, the CD3- CD56dim subset was expanded compared to healthy controls. We also studied the effect of antiretroviral therapy administered early in infection and found that NK cell subset distribution was partially restored after 6 months of antiretroviral therapy in primary infection, but not normalized. Recently, NK cells have been divided into CD27- and CD27+ subsets with different migratory and functional capacity and CD27-mediated NK cell activation has been described in mice. We therefore investigated whether CD27 and/or CD70 (CD27 ligand) expression on NK cells, and thus the distribution of these novel NK subsets, was altered in HIV-1-infected patients. We found up-regulated expression of both CD27 and CD70 on NK cells of patients, resulting in higher proportions of CD27high and CD70 high NK cells, and this phenomenon was more pronounced in chronic infection. Experiments conducted in vitro suggest that the high interleukin-7 levels found during HIV-1 infection may participate in up-regulation of CD70 on NK cell subsets. Imbalance of NK cell subsets and up-regulated expression of CD27 and CD70 initiated early in HIV-1 infection may indicate NK cell activation and intrinsic defects initiated by HIV-1 to disarm the innate immune response to the virus.

Original languageEnglish
Pages (from-to)164-170
Number of pages7
JournalImmunology
Volume123
Issue number2
DOIs
Publication statusPublished - Feb 2008

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Virus Diseases
Natural Killer Cells
HIV-1
Infection
CD70 Antigens
Interleukin-7
Innate Immunity
HIV Infections
Up-Regulation
Viruses

Keywords

  • Antiretroviral therapy
  • CD27
  • CD70
  • HIV-1
  • Immune activation
  • NK cells

ASJC Scopus subject areas

  • Immunology

Cite this

Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection. / Titanji, Kehmia; Sammicheli, Stefano; De Milito, Angelo; Mantegani, Paola; Fortis, Claudio; Berg, Louise; Kärre, Klas; Travi, Giovanna; Tassandin, Chiara; Lopalco, Lucia; Rethi, Bence; Tambussi, Giuseppe; Chiodi, Francesca.

In: Immunology, Vol. 123, No. 2, 02.2008, p. 164-170.

Research output: Contribution to journalArticle

Titanji, K, Sammicheli, S, De Milito, A, Mantegani, P, Fortis, C, Berg, L, Kärre, K, Travi, G, Tassandin, C, Lopalco, L, Rethi, B, Tambussi, G & Chiodi, F 2008, 'Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection', Immunology, vol. 123, no. 2, pp. 164-170. https://doi.org/10.1111/j.1365-2567.2007.02657.x
Titanji, Kehmia ; Sammicheli, Stefano ; De Milito, Angelo ; Mantegani, Paola ; Fortis, Claudio ; Berg, Louise ; Kärre, Klas ; Travi, Giovanna ; Tassandin, Chiara ; Lopalco, Lucia ; Rethi, Bence ; Tambussi, Giuseppe ; Chiodi, Francesca. / Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection. In: Immunology. 2008 ; Vol. 123, No. 2. pp. 164-170.
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