Altered dopamine modulation of LTD-like plasticity in Alzheimer's disease patients

Giacomo Koch, Zaira Esposito, Claudia Codecà, Francesco Mori, Hajime Kusayanagi, Fabrizia Monteleone, Francesco Di Lorenzo, Giorgio Bernardi, Alessandro Martorana

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective: Mechanisms of synaptic plasticity like long term depression (LTD) are altered in experimental models of Alzheimer's disease (AD). LTD-like plasticity mechanisms has not been yet fully investigated in AD patients. Methods: Here we studied the effects of low frequency (1. Hz) repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex in a group of patients with a diagnosis of probable AD, compared to healthy age-matched controls (HS). Moreover, we tested the effects of a single dose of orally administered L-dopa, one of the key neurotransmitters in modulating synaptic plasticity mechanisms, on rTMS induced plasticity. Results: We found that in AD patients the 1. Hz rTMS protocol did not induce the expected inhibitory effect, while a long lasting inhibition of MEP was observed in HS. In addition, L-dopa induced a clear form of reversal of the direction of plasticity in HS that was not evident in AD. Conclusions: Dopamine modulation of LTD-like plasticity is impaired when tested in AD patients. Significance: These findings provide evidence of possible dysfunction of dopaminergic transmission in AD patients.

Original languageEnglish
Pages (from-to)703-707
Number of pages5
JournalClinical Neurophysiology
Volume122
Issue number4
DOIs
Publication statusPublished - Apr 2011

Fingerprint

Dopamine
Alzheimer Disease
Depression
Transcranial Magnetic Stimulation
Neuronal Plasticity
Levodopa
Motor Cortex
Neurotransmitter Agents
Theoretical Models

Keywords

  • Alzheimer's disease
  • Cortical plasticity
  • Dopamine
  • LTD
  • RTMS
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Cite this

Koch, G., Esposito, Z., Codecà, C., Mori, F., Kusayanagi, H., Monteleone, F., ... Martorana, A. (2011). Altered dopamine modulation of LTD-like plasticity in Alzheimer's disease patients. Clinical Neurophysiology, 122(4), 703-707. https://doi.org/10.1016/j.clinph.2010.10.033

Altered dopamine modulation of LTD-like plasticity in Alzheimer's disease patients. / Koch, Giacomo; Esposito, Zaira; Codecà, Claudia; Mori, Francesco; Kusayanagi, Hajime; Monteleone, Fabrizia; Di Lorenzo, Francesco; Bernardi, Giorgio; Martorana, Alessandro.

In: Clinical Neurophysiology, Vol. 122, No. 4, 04.2011, p. 703-707.

Research output: Contribution to journalArticle

Koch, G, Esposito, Z, Codecà, C, Mori, F, Kusayanagi, H, Monteleone, F, Di Lorenzo, F, Bernardi, G & Martorana, A 2011, 'Altered dopamine modulation of LTD-like plasticity in Alzheimer's disease patients', Clinical Neurophysiology, vol. 122, no. 4, pp. 703-707. https://doi.org/10.1016/j.clinph.2010.10.033
Koch, Giacomo ; Esposito, Zaira ; Codecà, Claudia ; Mori, Francesco ; Kusayanagi, Hajime ; Monteleone, Fabrizia ; Di Lorenzo, Francesco ; Bernardi, Giorgio ; Martorana, Alessandro. / Altered dopamine modulation of LTD-like plasticity in Alzheimer's disease patients. In: Clinical Neurophysiology. 2011 ; Vol. 122, No. 4. pp. 703-707.
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