Altered drug binding to serum proteins in pregnant women: Therapeutic relevance

E. Perucca, M. Ruprah, A. Richens

Research output: Contribution to journalArticlepeer-review

Abstract

The binding of diazepam, phenytoin and valproic acid to serum proteins in vitro has been compared in pregnant women of different gestational ages and in controls. The unbound fraction of each of the three drugs was elevated during pregnancy (particularly during the last 8 weeks), probably due, at least in part, to a fall in serum albumin concentration. These findings may provide a partial explanation for the increase in the clearance of certain drugs during pregnancy and need to be taken into account when interpreting serum drug levels in clinical practice.

Original languageEnglish
Pages (from-to)422-426
Number of pages5
JournalJournal of the Royal Society of Medicine
Volume74
Issue number6
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Medicine(all)

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