Altered expression of a new antigen of the dermal-epidermal junction (NU-T2 DEJ Ag) in junctional epidermolysis bullosa

Gianluca Tadini, Jean Kanitakis, Riccardo Cavalli, Daniel Schmitt, Stefano Cambiaghi, Emilio Berti

Research output: Contribution to journalArticlepeer-review

Abstract

NU-T2 antigen (Ag) is a new and recently described antigen of the dermal-epidermal junction, recognized by an anti-CD1b monoclonal antibody denominated NU-T2. We studied NU-T2 Ag expression in junctional epidermolysis bullosa (13 patients) and in other forms of hereditary epidermolysis bullosa (23 patients), comparing the results with nicein expression. In junctional epidermolysis bullosa gravis type no differences were found between the expression of NU-T2 and nicein, both being negative in bullous as well as in non-bullous skin. Interestingly, in mitis type junctional epidermolysis bullosa, NU-T2 Ag was found to be absent or reduced in five of six patients both in lesional and in uncleaved skin. When compared with nicein expression, clearcut differences were found, further suggesting that these two antigens are different. These data confirm that NU-T2 Ag is a novel epitope of the dermal-epidermal junction, probably relevant in dermal-epidermal cohesion, and it could be responsible, together with nicein, 19-DEJ-1 and other adhesion molecules, for the different subtypes of junctional epidermolysis bullosa. Finally, NU-T2 monoclonal antibody is a new relevant tool for the diagnosis, classification, and prenatal diagnosis of junctional epidermolysis bullosa.

Original languageEnglish
Pages (from-to)699-704
Number of pages6
JournalArchives of Dermatological Research
Volume287
Issue number8
DOIs
Publication statusPublished - Aug 1995

Keywords

  • Dermal-epidermal junction
  • Junctional epidermolysis bullosa
  • Nicein
  • NU-T2 monoclonal antibody

ASJC Scopus subject areas

  • Dermatology

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