Altered expression of B lymphocyte surface immunoglobulins in minimal change nephrotic syndrome and focal glomerulosclerosis

P. Dall'Aglio, P. L. Meroni, W. Barcellini, C. Brigati, C. Chizzolini, G. De Bartolo, L. Migone, C. Zanussi

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Abstract

In 20 patients with nephrotic syndrome (10 minimal change glomerulonephritis, MCN; 10 focal glomerulosclerosis, FGS) the peripheral blood lymphocytes showed a statistically significant increased in IgG-bearing cells (SIgG-C) in comparison with 30 patients with other histological types of primary glomerulonephritis with and without nephrotic syndrome (14 and 16, respectively). In the same MCN and FGS patients the serum IgG levels were slightly decreased. Furthermore, 5 cases of MCN in sustained remission for 1 year after steroid therapy showed normalization of the SIgG-C and serum IgG levels. The possible significance of these phenomena in the pathogenesis of the hypo-IgG-globulinemia in MCN and FGS is discussed.

Original languageEnglish
Pages (from-to)224-228
Number of pages5
JournalNephron
Volume37
Issue number4
Publication statusPublished - 1984

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Lipoid Nephrosis
Focal Segmental Glomerulosclerosis
B-Cell Antigen Receptors
B-Lymphocytes
Immunoglobulin G
Nephrotic Syndrome
Glomerulonephritis
Serum
Steroids
Lymphocytes

ASJC Scopus subject areas

  • Nephrology

Cite this

Altered expression of B lymphocyte surface immunoglobulins in minimal change nephrotic syndrome and focal glomerulosclerosis. / Dall'Aglio, P.; Meroni, P. L.; Barcellini, W.; Brigati, C.; Chizzolini, C.; De Bartolo, G.; Migone, L.; Zanussi, C.

In: Nephron, Vol. 37, No. 4, 1984, p. 224-228.

Research output: Contribution to journalArticle

Dall'Aglio, P, Meroni, PL, Barcellini, W, Brigati, C, Chizzolini, C, De Bartolo, G, Migone, L & Zanussi, C 1984, 'Altered expression of B lymphocyte surface immunoglobulins in minimal change nephrotic syndrome and focal glomerulosclerosis', Nephron, vol. 37, no. 4, pp. 224-228.
Dall'Aglio, P. ; Meroni, P. L. ; Barcellini, W. ; Brigati, C. ; Chizzolini, C. ; De Bartolo, G. ; Migone, L. ; Zanussi, C. / Altered expression of B lymphocyte surface immunoglobulins in minimal change nephrotic syndrome and focal glomerulosclerosis. In: Nephron. 1984 ; Vol. 37, No. 4. pp. 224-228.
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AU - Brigati, C.

AU - Chizzolini, C.

AU - De Bartolo, G.

AU - Migone, L.

AU - Zanussi, C.

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AB - In 20 patients with nephrotic syndrome (10 minimal change glomerulonephritis, MCN; 10 focal glomerulosclerosis, FGS) the peripheral blood lymphocytes showed a statistically significant increased in IgG-bearing cells (SIgG-C) in comparison with 30 patients with other histological types of primary glomerulonephritis with and without nephrotic syndrome (14 and 16, respectively). In the same MCN and FGS patients the serum IgG levels were slightly decreased. Furthermore, 5 cases of MCN in sustained remission for 1 year after steroid therapy showed normalization of the SIgG-C and serum IgG levels. The possible significance of these phenomena in the pathogenesis of the hypo-IgG-globulinemia in MCN and FGS is discussed.

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